YIDC1_LISIN
ID YIDC1_LISIN Reviewed; 275 AA.
AC Q92BX6;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Membrane protein insertase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE Flags: Precursor;
GN Name=yidC1 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=lin1416;
OS Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=272626;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-680 / CLIP 11262;
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR EMBL; AL596168; CAC96647.1; -; Genomic_DNA.
DR PIR; AG1609; AG1609.
DR RefSeq; WP_010991523.1; NC_003212.1.
DR AlphaFoldDB; Q92BX6; -.
DR SMR; Q92BX6; -.
DR STRING; 272626.lin1416; -.
DR EnsemblBacteria; CAC96647; CAC96647; CAC96647.
DR KEGG; lin:lin1416; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_5_1_9; -.
DR OMA; GWAIIII; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000002513; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Protein transport; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT CHAIN 22..275
FT /note="Membrane protein insertase YidC 1"
FT /id="PRO_0000020386"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ SEQUENCE 275 AA; 30908 MW; A21E60562145E88F CRC64;
MKKKNIILIS VLLGALLLIT GCSMDPSQNT DGFFSTYLIQ PFTSFIMFVA KFVGGNYGIA
IIITTLLIRA LIMPLNLRTA KAQMGMQSKM AVAKPEIDEI QARLKRATSK EEQANIQKEM
MAVYSKYNIN PIQMGCLPLL IQMPILMAFY YAIRGSSEIA SHTFLWFNLG SPDMVLAIIA
GLVYLAQYFV SMIGYSPEQK KQMKIIGLMS PIMILFVSFT APSALALYWA VGGLFLAGQT
LLTKKLYMNK HPEIKVMEQE EKEFEQIVEE QNKEK