YIDC1_LISMO
ID YIDC1_LISMO Reviewed; 275 AA.
AC Q8Y7A9; Q9RPY8;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Membrane protein insertase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE Flags: Precursor;
GN Name=yidC1 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=lmo1379;
OS Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=169963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-679 / EGD-e;
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-275.
RC STRAIN=LO28 / Serovar 1/2c;
RX PubMed=10542190; DOI=10.1128/jb.181.21.6840-6843.1999;
RA Cotter P.D., Emerson N., Gahan C.G., Hill C.;
RT "Identification and disruption of lisRK, a genetic locus encoding a two-
RT component signal transduction system involved in stress tolerance and
RT virulence in Listeria monocytogenes.";
RL J. Bacteriol. 181:6840-6843(1999).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR EMBL; AL591978; CAC99457.1; -; Genomic_DNA.
DR EMBL; AF139908; AAF03934.1; -; Genomic_DNA.
DR PIR; AC1247; AC1247.
DR RefSeq; NP_464904.1; NC_003210.1.
DR RefSeq; WP_003722505.1; NZ_CP023861.1.
DR AlphaFoldDB; Q8Y7A9; -.
DR SMR; Q8Y7A9; -.
DR STRING; 169963.lmo1379; -.
DR PaxDb; Q8Y7A9; -.
DR DNASU; 987847; -.
DR EnsemblBacteria; CAC99457; CAC99457; CAC99457.
DR GeneID; 987847; -.
DR KEGG; lmo:lmo1379; -.
DR PATRIC; fig|169963.11.peg.1417; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_5_1_9; -.
DR OMA; GWAIIII; -.
DR PhylomeDB; Q8Y7A9; -.
DR BioCyc; LMON169963:LMO1379-MON; -.
DR Proteomes; UP000000817; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT CHAIN 22..275
FT /note="Membrane protein insertase YidC 1"
FT /id="PRO_0000020390"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ SEQUENCE 275 AA; 30927 MW; 840A111C198391F2 CRC64;
MKKKNIILIS VLLGALLLLT GCSMDPSQNT DGFFSTYLIQ PFTSFIMFVA KFVGGNYGIA
IIITTLLIRA LIMPLNLRTA KAQMGMQSKM AVAKPEIDEI QARLKRATSK EEQATIQKEM
MAVYSKYNIN PMQMGCLPLL IQMPILMAFY YAIRGSSEIA SHTFLWFNLG SPDMVLAIIA
GLVYLAQYFV SMIGYSPEQK KQMKIIGLMS PIMILFVSFT APSALALYWA VGGLFLAGQT
LLTKKLYMNK HPEIKVMEQE EKEFEQIVEE QKKEK
