ID   YIDC1_STAES             Reviewed;         290 AA.
AC   Q8CMK8;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Membrane protein insertase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Foldase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane integrase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane protein YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   Flags: Precursor;
GN   Name=yidC1 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=SE_1689;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR   EMBL; AE015929; AAO05288.1; -; Genomic_DNA.
DR   RefSeq; NP_765244.1; NC_004461.1.
DR   RefSeq; WP_002470121.1; NZ_WBME01000021.1.
DR   AlphaFoldDB; Q8CMK8; -.
DR   SMR; Q8CMK8; -.
DR   STRING; 176280.SE_1689; -.
DR   DNASU; 1057314; -.
DR   EnsemblBacteria; AAO05288; AAO05288; SE_1689.
DR   GeneID; 50018211; -.
DR   KEGG; sep:SE_1689; -.
DR   PATRIC; fig|176280.10.peg.1649; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_5_2_9; -.
DR   OMA; GWAIIII; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01811; YidC_type2; 1.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW   Protein transport; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   CHAIN           20..290
FT                   /note="Membrane protein insertase YidC 1"
FT                   /id="PRO_0000020399"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   REGION          270..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           20
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   LIPID           20
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ   SEQUENCE   290 AA;  33747 MW;  913063238F04D09E CRC64;
     MKKKALLPLF LGIMIFLAGC DYSTPEKQDG FFFNTFVQPM KHLLQWLGND VFHNNFGLAI
     IVLVLFIRLI LLPFMLSNYK NSHMMREKMK VAKPEVDGIQ EKVKRARTQE EKMAANQELM
     EVYKKYDMNP MKSMLGCLPI LIQMPIIMGL YFVLKDKLVN GLSEHPHFLW FNLTKPDIWI
     TVIAGVLYFI QAVVSSKTMP QEQRQMGYMM MVISPIMIIW ISLQASSALG LYWSVSALFL
     VIQTHFANIY YSKLAKKEVQ PFIEKYEREH NPYSKKKGKN TQVVSKKNKK