ID   YIDC1_STRMU             Reviewed;         271 AA.
AC   Q8DVX3;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Membrane protein insertase YidC 1;
DE   AltName: Full=Foldase YidC 1;
DE   AltName: Full=Membrane integrase YidC 1;
DE   AltName: Full=Membrane protein YidC 1;
DE   Flags: Precursor;
GN   Name=yidC1; OrderedLocusNames=SMU_337;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=NG8;
RX   PubMed=16293689; DOI=10.1073/pnas.0508778102;
RA   Hasona A., Crowley P.J., Levesque C.M., Mair R.W., Cvitkovitch D.G.,
RA   Bleiweis A.S., Brady L.J.;
RT   "Streptococcal viability and diminished stress tolerance in mutants lacking
RT   the signal recognition particle pathway or YidC2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:17466-17471(2005).
RN   [3]
RP   COMPLEMENTATION BY AND IN E.COLI.
RC   STRAIN=NG8;
RX   PubMed=18178746; DOI=10.1128/jb.01366-07;
RA   Dong Y., Palmer S.R., Hasona A., Nagamori S., Kaback H.R., Dalbey R.E.,
RA   Brady L.J.;
RT   "Functional overlap but lack of complete cross-complementation of
RT   Streptococcus mutans and Escherichia coli YidC orthologs.";
RL   J. Bacteriol. 190:2458-2469(2008).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins (By similarity). Partially complements an
CC       E.coli yidC depletion experiment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:16293689}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE014133; AAN58096.1; -; Genomic_DNA.
DR   RefSeq; NP_720790.1; NC_004350.2.
DR   RefSeq; WP_002264887.1; NC_004350.2.
DR   AlphaFoldDB; Q8DVX3; -.
DR   SMR; Q8DVX3; -.
DR   STRING; 210007.SMU_337; -.
DR   PRIDE; Q8DVX3; -.
DR   DNASU; 1027894; -.
DR   EnsemblBacteria; AAN58096; AAN58096; SMU_337.
DR   KEGG; smu:SMU_337; -.
DR   PATRIC; fig|210007.7.peg.292; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_5_0_9; -.
DR   OMA; WIMPIMI; -.
DR   PhylomeDB; Q8DVX3; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01811; YidC_type2; 1.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW   Protein transport; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..271
FT                   /note="Membrane protein insertase YidC 1"
FT                   /id="PRO_0000020404"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  31326 MW;  39AAB88F13444564 CRC64;
     MKKKYRIIGL AVAALLFLSA CGRSQVTSHS SDAWEKFVYF FAETIRFLSI NGRIGIGIIL
     FTFLIRTILL PLFNLQLKSG QKMQELQPEL KALQTKYPGK DRESRMRMAE ESQELYKKYG
     VNPYASLFPL LIQMPVLWAL YQALTRVEFL KTGSFLWMDI GNKDPYFILP VLAAIFTFLS
     SWLTNKAAKE RNGMMITMNI ILPIFILLIG FNLASGVALY WVVSNAYQVF QILLLNNPFK
     IIAERQRLED EARELEAKKR RAKKKAHKKR K