ID   YIDC1_STRP3             Reviewed;         275 AA.
AC   P0DC86; P65632; Q9A1J3;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Membrane protein insertase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Foldase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane integrase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane protein YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   Flags: Precursor;
GN   Name=yidC1 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=SpyM3_0176;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR   EMBL; AE014074; AAM78783.1; -; Genomic_DNA.
DR   RefSeq; WP_010921871.1; NC_004070.1.
DR   AlphaFoldDB; P0DC86; -.
DR   SMR; P0DC86; -.
DR   EnsemblBacteria; AAM78783; AAM78783; SpyM3_0176.
DR   GeneID; 57852040; -.
DR   KEGG; spg:SpyM3_0176; -.
DR   HOGENOM; CLU_036138_5_0_9; -.
DR   OMA; WIMPIMI; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01811; YidC_type2; 1.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW   Protein transport; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   CHAIN           26..275
FT                   /note="Membrane protein insertase YidC 1"
FT                   /id="PRO_0000020412"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        198..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        222..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ   SEQUENCE   275 AA;  31763 MW;  6DA196565B50EBFB CRC64;
     MRKVLRVKKN IKIARIVPLV LLLVACGRGE VTAQSSSGWD QLVYLFARAI QWLSFDGSIG
     VGIILFTLTI RLMLMPLFNM QIKSSQKMQD IQPELRELQR KYAGKDTQTR MKLAEESQAL
     YKKYGVNPYA SLLPLLIQMP VMIALFQALT RVSFLKTGTF LWVELAQHDH LYLLPVLAAV
     FTFLSTWLTN LAAKEKNVMM TVMIYVMPLM IFFMGFNLAS GVVLYWTVSN AFQVVQLLLL
     NNPFKIIAER QRLANEEKER RLRERRARKK AMKRK