YIDC2_ALKHC
ID YIDC2_ALKHC Reviewed; 280 AA.
AC Q9KDP2;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Membrane protein insertase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE Flags: Precursor;
GN Name=yidC2 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=BH1169;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR EMBL; BA000004; BAB04888.1; -; Genomic_DNA.
DR PIR; A83796; A83796.
DR PDB; 3WO6; X-ray; 2.40 A; A=27-266.
DR PDB; 3WO7; X-ray; 3.20 A; A/B=27-267.
DR PDBsum; 3WO6; -.
DR PDBsum; 3WO7; -.
DR AlphaFoldDB; Q9KDP2; -.
DR SMR; Q9KDP2; -.
DR STRING; 272558.10173785; -.
DR TCDB; 2.A.9.3.6; the membrane protein insertase (yidc/alb3/oxa1) family.
DR DNASU; 892166; -.
DR EnsemblBacteria; BAB04888; BAB04888; BAB04888.
DR KEGG; bha:BH1169; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_5_0_9; -.
DR OMA; QWPILIA; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT CHAIN 23..280
FT /note="Membrane protein insertase YidC 2"
FT /id="PRO_0000020376"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 23
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 23
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT HELIX 29..40
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 42..55
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 60..103
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 111..128
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 132..135
FT /evidence="ECO:0007829|PDB:3WO7"
FT HELIX 138..155
FT /evidence="ECO:0007829|PDB:3WO6"
FT TURN 157..161
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 176..193
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 216..222
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 224..235
FT /evidence="ECO:0007829|PDB:3WO6"
FT HELIX 238..255
FT /evidence="ECO:0007829|PDB:3WO6"
SQ SEQUENCE 280 AA; 32108 MW; 724F78BC47E7C270 CRC64;
MNYMKRRLLL FAGILLLVAL AGCSTTDPIT SESEGIWNHF FVYPMSWLIT TVANLLNGSY
GLSIIIVTIL IRLALLPLTL KQQKSMRAMQ VIRPEMEAIQ KKYKEKGSKD PKVQQEMQKE
LLGLYQKHGV NPMAGCLPLF IQLPILMAFY FAIMRTEEIR YHTFLWFDLG QPDYILPFVA
GITTYFQFKM TMSHQQQMQK TNPSDSDNPM ANMMQMQMKV MLYVMPVMII IAGLSLPSAL
SLYWVIGNIF MIIQTYFIVV KAPPLEVEQT KQKSSKPNKA
