ID   YIDC2_LACLA             Reviewed;         320 AA.
AC   Q9CHZ9;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   21-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Membrane protein insertase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Foldase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane integrase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane protein YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   Flags: Precursor;
GN   Name=yidC2 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=LL0569;
GN   ORFNames=L164312;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK04667.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005176; AAK04667.1; ALT_INIT; Genomic_DNA.
DR   PIR; A86696; A86696.
DR   RefSeq; NP_266725.1; NC_002662.1.
DR   RefSeq; WP_003130506.1; NC_002662.1.
DR   AlphaFoldDB; Q9CHZ9; -.
DR   SMR; Q9CHZ9; -.
DR   STRING; 272623.L164312; -.
DR   PaxDb; Q9CHZ9; -.
DR   EnsemblBacteria; AAK04667; AAK04667; L164312.
DR   GeneID; 60356905; -.
DR   GeneID; 66441484; -.
DR   KEGG; lla:L164312; -.
DR   PATRIC; fig|272623.7.peg.609; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_5_1_9; -.
DR   OMA; GWAIIII; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01811; YidC_type2; 1.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW   Protein transport; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   CHAIN           24..320
FT                   /note="Membrane protein insertase YidC 2"
FT                   /id="PRO_0000020382"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   REGION          270..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..313
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           24
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   LIPID           24
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ   SEQUENCE   320 AA;  35645 MW;  7F12C6A1707A1B0A CRC64;
     MKNLKKKLTL TGLMTAGLLF LSGCVQTHVV DGVRVPTEAA THGITYNFLV RPMSAFVDLF
     ANNLHMGYGW GIIFVTLIIR FLILPLGLNQ AYKSTYMQEK MAYLAPVFAP LQERLKKAQT
     PEEKMAAQQA LMAAQKDNGI NMLSSIGCLP MLIQWPFFIA LYNAAAYTTG ISSSTFYGIP
     LGHPSVVLVI ISGVLYFIQT WISTLSMTPE QKKSGMAMLI MSPAMIVVFS FMSPAGVALY
     WAVGGFVIVI QQIIITFIMK PRMRRRIDEE FTKNPPKINN EGLKDVTPTS VQENFKEITS
     ERNEKERKSG GRNAGKQNRK