YIDC2_LISMO
ID YIDC2_LISMO Reviewed; 287 AA.
AC Q8Y3I2; Q9RQH4;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Membrane protein insertase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE Flags: Precursor;
GN Name=yidC2 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=lmo2854;
OS Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=169963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-679 / EGD-e;
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 86-173.
RC STRAIN=ATCC BAA-679 / EGD-e;
RX PubMed=10746777; DOI=10.1099/00221287-146-3-731;
RA Milohanic E., Pron B., Berche P., Gaillard J.-L.;
RT "Identification of new loci involved in adhesion of Listeria monocytogenes
RT to eukaryotic cells.";
RL Microbiology 146:731-739(2000).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR EMBL; AL591984; CAD01067.1; -; Genomic_DNA.
DR EMBL; AF104228; AAF04771.1; -; Genomic_DNA.
DR PIR; AE1431; AE1431.
DR RefSeq; NP_466376.1; NC_003210.1.
DR RefSeq; WP_003723726.1; NZ_CP023861.1.
DR AlphaFoldDB; Q8Y3I2; -.
DR SMR; Q8Y3I2; -.
DR STRING; 169963.lmo2854; -.
DR PaxDb; Q8Y3I2; -.
DR DNASU; 986378; -.
DR EnsemblBacteria; CAD01067; CAD01067; CAD01067.
DR GeneID; 986378; -.
DR KEGG; lmo:lmo2854; -.
DR PATRIC; fig|169963.11.peg.2925; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_5_0_9; -.
DR OMA; WIMPIMI; -.
DR PhylomeDB; Q8Y3I2; -.
DR BioCyc; LMON169963:LMO2854-MON; -.
DR Proteomes; UP000000817; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT CHAIN 27..287
FT /note="Membrane protein insertase YidC 2"
FT /id="PRO_0000020389"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 207..224
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 228..250
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 27
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 27
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ SEQUENCE 287 AA; 32500 MW; 70ADD1D4CFD51A2A CRC64;
MKKKKRFKQK LLIASLVIGL MAVLSGCGYS TDPITSESTG FWSHYIVFPL SWTITWFSDL
FGGSYAVGII VVTILIRLLI MPLMIKQLKS QKAMTNLQPK IKELQEKYSS KDNETKQKLQ
QETMRLYQEN SVNPMMGCLP LLIQMPILLG FYQAISRTAE IKTDSFLWMQ LGNPDPYYIL
PVVAALTTFL SSKISMMGQT QQNKSMAMIV YIMPVMILFM GITLPSALAL YWIIGNIFTV
FQTLLINNPF KNKREQEALA AAQVAEDRLK KKAANMKASK KGGKKRK
