YIDC2_STAES
ID YIDC2_STAES Reviewed; 278 AA.
AC Q8CMK4;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Membrane protein insertase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE Flags: Precursor;
GN Name=yidC2 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=SE_2008;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR EMBL; AE015929; AAO05649.1; -; Genomic_DNA.
DR RefSeq; NP_765563.1; NC_004461.1.
DR RefSeq; WP_001832893.1; NZ_WBME01000003.1.
DR AlphaFoldDB; Q8CMK4; -.
DR SMR; Q8CMK4; -.
DR STRING; 176280.SE_2008; -.
DR DNASU; 1055953; -.
DR EnsemblBacteria; AAO05649; AAO05649; SE_2008.
DR GeneID; 50017903; -.
DR KEGG; sep:SE_2008; -.
DR PATRIC; fig|176280.10.peg.1961; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_5_2_9; -.
DR OMA; NIGCLPI; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Protein transport; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT CHAIN 19..278
FT /note="Membrane protein insertase YidC 2"
FT /id="PRO_0000020398"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ SEQUENCE 278 AA; 32335 MW; B0B649E0B22BB1C1 CRC64;
MHKRLFITLL GFIILLAGCD YSKEENQTGI FYNVFVKSMD GFLHFLGRVF QDNYGFAIIS
IVLIVRFILL PFMLIQVKNM HMMREKTKVV QPELDAIRDK MKHATSQEER NAANQLLMKK
YQSYGINPLK NMLGCLPVLI QMPILMGLYM SLKYPSSHGI TEYPHFLWFD LTQPDLIMTI
IAAIMYFVQP LVNSIHYPKD QRKTYYFMMV FSPIFITYAS LHSAAALGLY WSISAAFLIV
QMHFAHSHYK KVALHEAKKL KQKLEQNKDN SELLTEES
