ID   YIDC2_STRA5             Reviewed;         310 AA.
AC   Q8DY84;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Membrane protein insertase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Foldase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane integrase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   AltName: Full=Membrane protein YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE   Flags: Precursor;
GN   Name=yidC2 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=SAG1608;
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R;
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA   Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA   Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA   Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA   Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR   EMBL; AE009948; AAN00472.1; -; Genomic_DNA.
DR   RefSeq; NP_688599.1; NC_004116.1.
DR   RefSeq; WP_000751931.1; NC_004116.1.
DR   AlphaFoldDB; Q8DY84; -.
DR   SMR; Q8DY84; -.
DR   STRING; 208435.SAG1608; -.
DR   EnsemblBacteria; AAN00472; AAN00472; SAG1608.
DR   KEGG; sag:SAG1608; -.
DR   PATRIC; fig|208435.3.peg.1618; -.
DR   HOGENOM; CLU_036138_5_1_9; -.
DR   OMA; GWAIIII; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01811; YidC_type2; 1.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW   Protein transport; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   CHAIN           24..310
FT                   /note="Membrane protein insertase YidC 2"
FT                   /id="PRO_0000020403"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   REGION          266..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           24
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT   LIPID           24
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ   SEQUENCE   310 AA;  34735 MW;  397AD7FCC52840CD CRC64;
     MKKTLKRILF SSLSLSMLLL LTGCVSVDKA GKPYGVIWNT LGVPMANLIT YFAQHQGLGF
     GVAIIIVTVI VRVVILPLGL YQSWKASYQA EKMAYFKPLF EPINERLRNA KTQEEKLAAQ
     TELMTAQREN GLSMFGGIGC LPLLIQMPFF SAIFFAARYT PGVSSATFLG LNLGQKSLTL
     TVIIAILYFV QSWLSMQGVP DEQRQQMKTM MYLMPIMMVF MSISLPASVA LYWFIGGIFS
     IIQQLVTTYV LKPKLRRKVE EEYTKNPPKA YKANNARKDV TNSTKATESN QAIITSKKTN
     RNAGKQKRRG