YIDC2_STRP1
ID YIDC2_STRP1 Reviewed; 307 AA.
AC Q9A1C3; Q490Q4;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Membrane protein insertase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC 2 {ECO:0000255|HAMAP-Rule:MF_01811};
DE Flags: Precursor;
GN Name=yidC2 {ECO:0000255|HAMAP-Rule:MF_01811};
GN OrderedLocusNames=SPy_0351, M5005_Spy0295;
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX PubMed=16088826; DOI=10.1086/432514;
RA Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA Musser J.M.;
RT "Evolutionary origin and emergence of a highly successful clone of serotype
RT M1 group A Streptococcus involved multiple horizontal gene transfer
RT events.";
RL J. Infect. Dis. 192:771-782(2005).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR EMBL; AE004092; AAK33400.1; -; Genomic_DNA.
DR EMBL; CP000017; AAZ50914.1; -; Genomic_DNA.
DR RefSeq; NP_268679.1; NC_002737.2.
DR AlphaFoldDB; Q9A1C3; -.
DR SMR; Q9A1C3; -.
DR STRING; 1314.HKU360_00333; -.
DR PaxDb; Q9A1C3; -.
DR EnsemblBacteria; AAK33400; AAK33400; SPy_0351.
DR KEGG; spy:SPy_0351; -.
DR KEGG; spz:M5005_Spy0295; -.
DR PATRIC; fig|160490.10.peg.302; -.
DR HOGENOM; CLU_036138_5_1_9; -.
DR OMA; GWAIIII; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT CHAIN 24..307
FT /note="Membrane protein insertase YidC 2"
FT /id="PRO_0000020411"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 209..225
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT REGION 263..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 24
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 24
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ SEQUENCE 307 AA; 34506 MW; 4D0E523F39640D2C CRC64;
MKLTLNRILF SGLALSILLT LTGCVGRDAH GNPKGMIWEF LGKPMSYFID YFANNAGLGY
GLAIIIVTII VRTLILPLGL YQSWKASYQS EKMAFLKPVF EPINKRIKQA NSQEEKMAAQ
TELMAAQRAH GINPLGGIGC LPLLIQMPFF SAMYFAAQYT KGVSTSTFMG IDLGSRSLVL
TAIIAALYFF QSWLSMMAVS EEQREQMKTM MYTMPIMMIF MSFSLPAGVG LYWLVGGFFS
IIQQLITTYL LKPRLHKQIK EEYAKNPPKA YQSTSSRKDV TPSQNMEQAN LPKKIKSNRN
AGKQRKR
