ID   YIDC_AERHH              Reviewed;         548 AA.
AC   A0KQZ7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=AHA_4281;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS   13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC   2358 / NCIMB 9240 / NCTC 8049;
RX   PubMed=16980456; DOI=10.1128/jb.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP000462; ABK35833.1; -; Genomic_DNA.
DR   RefSeq; WP_011707925.1; NC_008570.1.
DR   RefSeq; YP_858698.1; NC_008570.1.
DR   AlphaFoldDB; A0KQZ7; -.
DR   SMR; A0KQZ7; -.
DR   STRING; 380703.AHA_4281; -.
DR   EnsemblBacteria; ABK35833; ABK35833; AHA_4281.
DR   GeneID; 64360806; -.
DR   KEGG; aha:AHA_4281; -.
DR   PATRIC; fig|380703.7.peg.4230; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_3_0_6; -.
DR   OMA; INPVAGC; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..548
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000070051"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   548 AA;  61732 MW;  3716FB304E06EA48 CRC64;
     MESQRNLILI GLLFVSFLLW QQWESDKAPK PAPTTVAQTE HFVPEAGQTG DIPQVSEQAN
     ANTARKLITV SSDVLKLTLD TQGGDIVSAD LLAHKLEEGK DQPFVLLTSQ PEHLYVAQSG
     LVGRNGPDSQ AQGRPTYEAA QTSYQLADGQ DQVVVPMTWT DSKGVVFTKE FVLKRGDYAV
     GVDYKIDNKS AEPVQVQFYG QLKQTVTTPK DQQGHAMVAS AYRGGAFSSE DTRYKKYTFD
     EMKDADLNKT TKGGWVAMLQ HYFVSAWAPN ADDTNSFYSR VIPGKDQAII GYKAPLVDVA
     AGQQAEVTSK LWVGPKLQDQ MAKVANHLDL TVDYGWLWFI AQPLHWLLTV FHGFVQNWGV
     AIIMLTLLVR GIMFPLTKAQ YTSMAKMRML QPKLAALRER FGDDRQKMSQ GMMELYKKEK
     VNPLGGCLPI LVQMPIFIAL YWALMESVEL RHAPFALWIT DLSVKDPFFV LPILMGASMW
     YLQKMSPTTI TDPMQQKVMQ FMPIIFTFMF LWFPAGLTLY WLVSNVISIT QQTIIYRQLE
     KKGLHTRS