ID   YIDC_BACFR              Reviewed;         618 AA.
AC   Q64T26;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BF2603;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01810};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; AP006841; BAD49353.1; -; Genomic_DNA.
DR   RefSeq; WP_005815482.1; NC_006347.1.
DR   RefSeq; YP_099887.1; NC_006347.1.
DR   AlphaFoldDB; Q64T26; -.
DR   SMR; Q64T26; -.
DR   STRING; 295405.BF2603; -.
DR   EnsemblBacteria; BAD49353; BAD49353; BF2603.
DR   GeneID; 66328338; -.
DR   KEGG; bfr:BF2603; -.
DR   PATRIC; fig|295405.11.peg.2513; -.
DR   HOGENOM; CLU_016535_2_0_10; -.
DR   OMA; WGIFGWI; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..618
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000070059"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        478..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        520..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        545..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   618 AA;  70883 MW;  B871BA1783032FF9 CRC64;
     MDKNTITGLV LIGILLVGFS FLSRPSEEQI AAQKRYYDSI AVVQQQEEAL RAKTEAALAN
     EKEETAADSA SLFFNATKGK EAFTTIQNNL VEITLDNKGG RVYSALLKNY MGQDKKPVVL
     FNGSDASMNF NFYNKKGALQ TKDFYFEAVN KTDSSVTMRL AADSASYIDF IYTLKPDNYL
     MSFVIKATGM DGKLAASTNY VDISWSQRAR QIEKGYTYEN RLADLTYKYT GDDVDNLSAS
     KDDEKSVSER LDWIAFKNQF FSSVFIAEQD FEKTTVKSKM EKQGSGYIKD YSAEMSTFFD
     PTGKQPTDMY FYFGPNHYKT LTALDKGREE KWELNNLVYL GWPLIRWINK WITINVFDWL
     SGWGLSMGIV LLLLTIMVKI VVFPATWKTY MSSAKMRVLK PKIDEINKKY PKQEDAMKKQ
     QEVMGLYSQY GVSPMGGCLP MLLQFPILMA LFMFVPSAIE LRQQSFLWAD DLSTYDAFIT
     FPFHIPFLGN HLSLFCLLMT VTNILNTKYT MQQQDTGAQP QMAAMKWMMY LMPIMFLFVL
     NDYPSGLNYY YFISTLISVV TMIILRRTTD ENKLLTELEA KKKDPKQMKK TGFAARLEAM
     QKQQEQLAKE RANKQNKK