ID   YIDC_BACTN              Reviewed;         618 AA.
AC   Q8AA76;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BT_0589;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01810};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; AE015928; AAO75696.1; -; Genomic_DNA.
DR   RefSeq; NP_809502.1; NC_004663.1.
DR   RefSeq; WP_008763174.1; NC_004663.1.
DR   AlphaFoldDB; Q8AA76; -.
DR   SMR; Q8AA76; -.
DR   STRING; 226186.BT_0589; -.
DR   PaxDb; Q8AA76; -.
DR   PRIDE; Q8AA76; -.
DR   EnsemblBacteria; AAO75696; AAO75696; BT_0589.
DR   GeneID; 60926546; -.
DR   KEGG; bth:BT_0589; -.
DR   PATRIC; fig|226186.12.peg.590; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_2_0_10; -.
DR   InParanoid; Q8AA76; -.
DR   OMA; WGIFGWI; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR   GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..618
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124687"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        442..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        523..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        548..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   618 AA;  70524 MW;  D7059EC0AD43425D CRC64;
     MDKNTITGLV LIGILLVGFS YLSRPSEEQI AAQKKYYDSI AVVQQQQEAL KAKTEAALAN
     ENKGAAAAAD SSALFFNAMH GTDSKVSIQN SVAEITFTTK GGRVYSAMLK EYKGQDKTNP
     VVLFDGDDAT MSFNFYNKQG AIQTKDYYFE AVNKTDSSVT MRLAADNASY IDFIYTLKPN
     SYLMNFEIKA TGMEGKLAST EYVDIDWTQR ARQLEKGFTY ENRLSELTYK VKGDNVDNLS
     AAKDDEKDLG NTAIDWVAFK NQFFSSVFIA DQDFNKVSVK SRMEQQGSGY IKDYSAEMST
     FFDPSGKQPT EMYFYFGPNH FKTLKALDKG RTEKWELNRL VYLGWPLIRW INQFITINVF
     DWLSGWGLSM GIVLLILTIM VKVVVYPATW KTYMSSAKMR VLKPKIDEIN KKYPKQEDAM
     KKQQEVMSLY SQYGVSPMGG CLPMLLQFPI LMALFMFVPS AIELRQQSFL WADDLSTYDA
     FITFPFHIPF LGNHLSLFCL LMTVTNILNT KYTMTMQDTG AQPQMAAMKW MMYLMPIMFL
     FVLNDYPSGL NYYYFVSTLI SVGTMILLRK TTDETKLLAI LEAKKKDPKQ MKKTGFAARL
     EAMQKQQEQL QQQKQNKR