YIDC_BEII9
ID YIDC_BEII9 Reviewed; 604 AA.
AC B2IDV5;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=Bind_3328;
OS Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB
OS 8712).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Beijerinckiaceae; Beijerinckia.
OX NCBI_TaxID=395963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 9039 / DSM 1715 / NCIMB 8712;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N.,
RA Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P.;
RT "Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC
RT 9039.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001016; ACB96887.1; -; Genomic_DNA.
DR RefSeq; WP_012386235.1; NC_010581.1.
DR AlphaFoldDB; B2IDV5; -.
DR SMR; B2IDV5; -.
DR STRING; 395963.Bind_3328; -.
DR PRIDE; B2IDV5; -.
DR EnsemblBacteria; ACB96887; ACB96887; Bind_3328.
DR KEGG; bid:Bind_3328; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_1_0_5; -.
DR OMA; INPVAGC; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000001695; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..604
FT /note="Membrane protein insertase YidC"
FT /id="PRO_1000187630"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 42..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 67670 MW; B05F06E6FDBF1B37 CRC64;
MKQDSRNLYL AIGLSLLVLI GWNYFFAGPQ VEKARQAQIV REQQAQTQTT SDTTARSDLN
VPGQRSLPGE SPQTQLSRPE ALAASPRVKL DTPNLFGSIN LRGARIDDVS LKAYRETVAK
DSPNIVLLSP SGTPAPYYAD AGFVAPAEAG LLLPKSDTLW SADREVLTPE APVTLTYDNG
QGLIFHRTIS VDDRFMFTLT DKVENKTDKP VTLYPYSLVS RHGRPVTAGY AVLHEGMVGV
IGDNGLQEIT YDKIHKEENA TKSFKGTGGW LGFTDKYWAA VIAPDQATPF EGRFSERGTT
TPLYQTDALG PALTIAPGGT GGDMSRLFAG AKETQTLDDY RNELGIKKFD LLIDWGYFYF
ITRPMFWILH TIYQVVGNFG VAILCITVLV KAVFFPLANR SYLSMAKMKA IQPQMLALRE
RYADDKVKQQ QELMELYKRE KINPVAGCLP MLIQIPVFFA LYKVLFVTIE MRQAPFFGWI
RDLSAPDPTN IFNLFGLLPF DPTHLPMIGH FLAIGIWPLI MGVSMFFQMK MNPEPADPVQ
KQMFSWMPVI FTFMLGTFPS GLVIYWTWNN TLSVLQQSLI MKRAGVKVEL WDNLMSTFRK
KAVT
