ID   YIDC_BIFLO              Reviewed;         335 AA.
AC   Q8G6J6;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=BL0644;
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE014295; AAN24466.1; -; Genomic_DNA.
DR   RefSeq; NP_695830.1; NC_004307.2.
DR   RefSeq; WP_007051771.1; NC_004307.2.
DR   AlphaFoldDB; Q8G6J6; -.
DR   SMR; Q8G6J6; -.
DR   STRING; 206672.BL0644; -.
DR   PRIDE; Q8G6J6; -.
DR   EnsemblBacteria; AAN24466; AAN24466; BL0644.
DR   GeneID; 66506175; -.
DR   KEGG; blo:BL0644; -.
DR   PATRIC; fig|206672.9.peg.1375; -.
DR   HOGENOM; CLU_036138_3_1_11; -.
DR   OMA; ERYKNDR; -.
DR   PhylomeDB; Q8G6J6; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..335
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124688"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          277..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..320
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   335 AA;  38128 MW;  537F99658362C3C7 CRC64;
     MNSNEFLLDS GFWGFLYKIL TPVEWLQTWI MKIVHDFFVM LGVSPIGVSW VLAIIILVLV
     VQACIFPLFY KQMKSMRKMQ ALAPKMQRIQ NKYKGKTDQA SREAMSRETM KLYQDNDVNP
     AGSCLPMLIQ GPVFMSMFYT LSAIPYIANG KRDALGAFDV ATAKQFTQTD VFGIVSVTDN
     FTSAAASGKA VIGIFVFLMC FCLWFMQYFS MKRNMAAASM NKQTETMQKA MLWLFPVMYI
     FSGVAMPFAV LVYWLTNNVC NLCRTLWQVY AFPTPGSPAA ADKEKRDHRN ENARRAKAGL
     PSLEEEALAK AKEEAERKAT QGYQRQQPVR KRKKK