ID   YIDC_BORBZ              Reviewed;         544 AA.
AC   B7J208;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BbuZS7_0448;
OS   Borreliella burgdorferi (strain ZS7) (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=445985;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZS7;
RX   PubMed=20935092; DOI=10.1128/jb.01158-10;
RA   Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J.,
RA   Mongodin E.F., Luft B.J.;
RT   "Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.";
RL   J. Bacteriol. 193:1018-1020(2011).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP001205; ACK74670.1; -; Genomic_DNA.
DR   RefSeq; WP_002657916.1; NC_011728.1.
DR   AlphaFoldDB; B7J208; -.
DR   SMR; B7J208; -.
DR   EnsemblBacteria; ACK74670; ACK74670; BbuZS7_0448.
DR   GeneID; 56567873; -.
DR   KEGG; bbz:BbuZS7_0448; -.
DR   HOGENOM; CLU_016535_2_0_12; -.
DR   OMA; MPIMFFF; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000006901; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..544
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000187631"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   544 AA;  63970 MW;  4F6F17F05D925DC9 CRC64;
     MNQSRRILRT VYLSLFLIGL FMLINDIFSS NILSSKSSDK EVQFDLNKSF DDNEISSVKS
     NSFNLINKSQ DIVVETGIYV ATFSTFKGNL VSLKLKNHLN LEKNPTDLIN IDRKNETFFD
     ISFDYFVDDL FLYKKIDDFN HEFKAYFKNN GKTYEYVKKY TFSKKDEYLM KFKVTVNGLE
     DYNLFDFDSY KIIFSSEIER LSDKAKLQYN NYLSQIIYYD NKLKYGKDGL RINNPRWIGS
     STKYFGVLVS KENMEVEFKK ERGTLKSFII NNVRNKKNIS DEFFIYAGPK DNRYLDVFDK
     RDDNTFGLFD IFFGMSVEKS FWYLIQVPMQ MVMQVFYDVI PNWGLSIIFL TIVVRILIFP
     LTFKGFRATA ELSKLQPKMK ELQAKFKHDP KKLNEEMGRL YKEEGVNPLG GCLPVILQLP
     IFFALYSLVN NLFLLRGASF IPGWIDDLSI GDSVYHFGYK LYFVSWTDIR ILPFIMMFTQ
     LGSTIVSSNM DLKNLGAQQK FLYFGMPIMF FFILYNMPSG LLIYWITTNI FTILQQYYIK
     MHLS