ID   YIDC_BORGP              Reviewed;         544 AA.
AC   Q661H9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BG0449;
OS   Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 /
OS   PBi) (Borrelia bavariensis).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=290434;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2496 / DSM 23469 / PBi;
RX   PubMed=15547252; DOI=10.1093/nar/gkh953;
RA   Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U.,
RA   Schilhabel M., Wilske B., Suehnel J., Platzer M.;
RT   "Comparative analysis of the Borrelia garinii genome.";
RL   Nucleic Acids Res. 32:6038-6046(2004).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP000013; AAU07292.1; -; Genomic_DNA.
DR   RefSeq; WP_011193762.1; NZ_CP028872.1.
DR   AlphaFoldDB; Q661H9; -.
DR   SMR; Q661H9; -.
DR   STRING; 290434.BG0449; -.
DR   EnsemblBacteria; AAU07292; AAU07292; BG0449.
DR   KEGG; bga:BG0449; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_2_0_12; -.
DR   OMA; MPIMFFF; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000002276; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..544
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000070063"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   544 AA;  63758 MW;  68E0C7AFCADB3D8B CRC64;
     MNQSKKILRT VYLSLFLIGL FMLINDIFSS IMLSFKSSDK EVQFDLNKSF DDNEIFLSKS
     NGFDLINKSQ NIVVETEIYF ATFSTFRGNL VSLKLKNHLN LEKDPTDLIN VDYKNETFFD
     VSLDYLVEDL FLYKKIDNLN HEFKAYFKNH GKIYEYVKKY TFSEKNEYLM KFTVIVNSLN
     DYDLFDIDSY KIVFSSEIER LSDKAKLQYN NYLSQIIYYD NKLKYGKDGL SINNPRWIGS
     STKYFEVLIS RENMEVEFKK ERGVLKSFIV NNVGNKKNIS DEFFIYAGPK DNRYLDIFDK
     SGDNTFGLSD IAFGMSVEKS LWYLIQVPMQ MVMQVFYDVI PNWGLSIIFL TIVVRILIFP
     LTFKGFRATA ELSKLQPKMK ELQVKFKHDP KKLNEEMGRL YKEEGVNPLG GCFPVILQLP
     IFFALYSLVN NLFLLRGASF IPGWIDDLSI GDSVYNFGYR LYFVSWTDIR ILPFIMMFTQ
     LGSTIVSSNL DLKNLGAQQK FLYFGMPIMF FFILYNMPSG LLIYWITTNI FTILQQYYIK
     MHLS