YIDC_BRUME
ID YIDC_BRUME Reviewed; 610 AA.
AC Q8YDA3;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BMEII0275;
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL53516.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE008918; AAL53516.1; ALT_INIT; Genomic_DNA.
DR PIR; AI3543; AI3543.
DR RefSeq; WP_004682443.1; NZ_GG703779.1.
DR AlphaFoldDB; Q8YDA3; -.
DR SMR; Q8YDA3; -.
DR STRING; 224914.BMEII0275; -.
DR EnsemblBacteria; AAL53516; AAL53516; BMEII0275.
DR GeneID; 29596016; -.
DR KEGG; bme:BMEII0275; -.
DR PATRIC; fig|224914.52.peg.3113; -.
DR eggNOG; COG0706; Bacteria.
DR OMA; INPVAGC; -.
DR PhylomeDB; Q8YDA3; -.
DR Proteomes; UP000000419; Chromosome II.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..610
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124694"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 36..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 69051 MW; FB13B7D1B5C1652D CRC64;
MENKRNFFIT IALSILILAL WQVFYLGPKT EAQREQARIE EQQRQAQQAA QNRQASSSTG
DTPQMPANPD SIPGQGDTKA AGAPLTRDAA IAQSPRIEID TPSLRGSINL TGARLDDLYL
KKYHETVSDK SPEIELLAPS SLKQGYFVEL GFTGNDATGA VPGPNTVWVV EGNNKLTPST
PVTLTYTNDK NLTFKRVISV DDAYMFTVDD TIINNGGSTV SLASYGRVTR FNQPEHASAT
YVLHEGLIGV MGQDGLQEIK YAKIEDNKDI SFKDVIGGWV GITDKYWAAT LIPPQDEKFT
GRFSHFTNDR PRYQSDLLSA PLTVAPGQSQ KIQNRVFAGA KVVNTIQNYE TKYHIKQFDL
LIDWGWFYFI TKPMFYLIDW IYKFTGNFGV AILVVTVLLK ALFFPLANKS YKSMARMKLM
QPKMTEIREK YADDKMKQQQ AMMELYKREK INPLAGCWPV LVQIPVFFAL YKVLYVTIEM
RHAPFFGWIQ DLAAPDPTSI FNLFGLLPYT VPHFLMIGVW PIIMGIIMFL QMRMNPTPPD
PTQAAIFTWM PIIFTFMLAS FPAGLVIYWA WNNTLSIIQQ SVIMKRQGVK IELFDNLKGL
FRRKPKEANK
