YIDC_BUCAP
ID YIDC_BUCAP Reviewed; 536 AA.
AC P29431;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2002, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BUsg_016;
OS Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=198804;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Anwarul H.K., Moriya S., Baumann P., Yoshikawa H., Ogasawara N.;
RT "The nucleotide sequence of 60K, tdhF, groES and groEL genes of Buchnera
RT aphidicola.";
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9516544; DOI=10.1007/pl00006760;
RA Clark M.A., Baumann L., Baumann P.;
RT "Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera
RT aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon,
RT gidA, and rho.";
RL Curr. Microbiol. 36:158-163(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sg;
RX PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-273.
RX PubMed=1572539; DOI=10.1016/0378-1119(92)90393-4;
RA Lai C.-Y., Baumann P.;
RT "Genetic analysis of an aphid endosymbiont DNA fragment homologous to the
RT rnpA-rpmH-dnaA-dnaN-gyrB region of eubacteria.";
RL Gene 113:175-181(1992).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM67588.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D85628; BAA12844.1; -; Genomic_DNA.
DR EMBL; AF008210; AAC38102.1; -; Genomic_DNA.
DR EMBL; AE013218; AAM67588.1; ALT_INIT; Genomic_DNA.
DR EMBL; M80817; AAA73145.1; -; Genomic_DNA.
DR PIR; JC1157; JC1157.
DR RefSeq; WP_044006072.1; NC_004061.1.
DR AlphaFoldDB; P29431; -.
DR SMR; P29431; -.
DR STRING; 198804.BUsg_016; -.
DR EnsemblBacteria; AAM67588; AAM67588; BUsg_016.
DR KEGG; bas:BUsg_016; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_3_0_6; -.
DR OMA; INPVAGC; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000000416; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..536
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124697"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT CONFLICT 367
FT /note="L -> V (in Ref. 1; BAA12844 and 2; AAC38102)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 536 AA; 62660 MW; 27A7C397679D7707 CRC64;
MELQRNFFIF AFLFVSFLLW QAWQSQSLKK NKKNEETNSF FHLNHKKEDK NQIIIKNDVL
RLVINMYGGD IEEASLLDYK TQLNSPENLK LLETKSDFVY QAQSGLIGKD GLDNSINKIR
PLYSAKKNFF ELGHNEKELR VPITFIAKNG ITYIKNFILK PGKYNVEVEY DINNLSNKKL
ELNIFGQLKQ TVKLPKNRDI YSGNFALQTF RGAAYSSSDA KYEKYKFDNI ANHEHLHIIT
HHGWIAMLQQ YFVVAWVPDT NISSSNIIYT SYLDNDGIAI IGYKSSLINI PSNSRYIIKS
KLWIGPEKQQ EMALVAPNLD LTVDYGFLWF LSQPLFKLLS TIHNFIGNWG FSIILITFMM
KAITYPLTKA QYTSMSKMRE LQPKINELKK NFGHDKQRMS KEIMALYKKE KINPLGGCLP
VFIQMPIFLS LYYMLIGSVE LRHAPFLFWI KDLSDQDPYY VLPIFMGLTM FFIQRTSSNN
ISDPFQQKIM HFMPFIFTVF FLWFPSGLVL YYIVSNLVTI IQQKYILSNF KKNQKR
