ID   YIDC_BUCMP              Reviewed;         240 AA.
AC   O51829;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
DE   Flags: Fragment;
GN   Name=yidC;
OS   Buchnera aphidicola subsp. Myzus persicae (Myzus persicae primary
OS   endosymbiont).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=98795;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9420234; DOI=10.1128/jvi.72.1.358-365.1998;
RA   Hogenhout S.A., van der Wilk F., Verbeek M., Goldbach R.W.,
RA   van den Heuvel J.F.J.M.;
RT   "Potato leafroll virus binds to the equatorial domain of the aphid
RT   endosymbiotic GroEL homolog.";
RL   J. Virol. 72:358-365(1998).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF003957; AAC04234.1; -; Genomic_DNA.
DR   AlphaFoldDB; O51829; -.
DR   SMR; O51829; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           <1..240
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124699"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   240 AA;  28045 MW;  926C8A63B9FEBA95 CRC64;
     SRTLIKSKLW VGPEIQKEMK LVAPNLDLTV DYGWLWFLSQ PLFKLLTIIN SIINNWGFSI
     ILITFIMKII TYPLTKSQYV SMSKIRALQP KIKEIKEAFS DNKQRISQEM IILYKKEKIN
     PLGGFLPVFI QMPVFLSLYY MLIGSVELRH APFVLWIKDL SSQDPFYVLP IIMGLTMFFI
     QKTSSNNISD PIQKKIMNFM PVIFTVFFLW FPSGLVLYYI VSNLVTIIQQ KFIFSNFKSN