YIDC_BURL3
ID YIDC_BURL3 Reviewed; 555 AA.
AC Q39BQ2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN OrderedLocusNames=Bcep18194_A6520;
OS Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 /
OS R18194 / 383).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=482957;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A.,
RA Richardson P.;
RT "Complete sequence of chromosome 1 of Burkholderia sp. 383.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; CP000151; ABB10114.1; -; Genomic_DNA.
DR RefSeq; WP_011353615.1; NZ_CABVQB010000020.1.
DR AlphaFoldDB; Q39BQ2; -.
DR SMR; Q39BQ2; -.
DR EnsemblBacteria; ABB10114; ABB10114; Bcep18194_A6520.
DR GeneID; 45096389; -.
DR KEGG; bur:Bcep18194_A6520; -.
DR PATRIC; fig|482957.22.peg.3554; -.
DR HOGENOM; CLU_016535_3_0_4; -.
DR OMA; INPVAGC; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000002705; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..555
FT /note="Membrane protein insertase YidC"
FT /id="PRO_1000070075"
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ SEQUENCE 555 AA; 61098 MW; E023C7C8F27F52CE CRC64;
MDIKRTVLWV IFFMSAVMLY DNWQRSHGRP SMFFPSATQT APAAAAGGAS GTGATTTTAG
EVPAAAAGAA PSTTAPAAQA QLVKFSTDVY DGEIDTRGGT LAKLTLKKQG DGKQPDLYIT
LFDHTAGHTY LARSGLLGGD FPNHNDVYTQ LNPGTTSLTG DQNALKLSFE SPVKGGVKVV
KTYTFTRGSY VIGVDTKIDN VGTAPVTPTV YMELVRDNTA VETPMFSHTF LGPAVYTDAK
HFQKINFSDL DKNKADYVTS ADNGWVAMVQ HYFASAWIPQ QGVKRDIYAE KIDPTLYRVG
VKQPVAAIAP GQSADVQARL FAGPEEERML EGIAPGLELV KDYGWVTIIA KPLFWLLEKI
HSYIGNWGWS IVLLTLLIKA VFFPLSAASY KSMARMKEIT PRMQALRERF KSDPQKMNSA
LMELYKTEKV NPFGGCLPVV IQIPVFISLY WVLLASVEMR GAPWVLWIHD LSQRDPFFIL
PVLMAVSMYV QTSLNPTPPD PVQAKMMKFM PIAFSVMFFF FPAGLVLYYV VNNVLSIAQQ
YYITRKLGGA KKKPA
