YIDC_CALS4
ID YIDC_CALS4 Reviewed; 206 AA.
AC Q8R6K6;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Membrane protein insertase YidC;
DE AltName: Full=Foldase YidC;
DE AltName: Full=Membrane integrase YidC;
DE AltName: Full=Membrane protein YidC;
GN Name=yidC; OrderedLocusNames=TTE2799;
OS Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Caldanaerobacter.
OX NCBI_TaxID=273068;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX PubMed=11997336; DOI=10.1101/gr.219302;
RA Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA Wang J., Yu J., Yang H.;
RT "A complete sequence of the T. tengcongensis genome.";
RL Genome Res. 12:689-700(2002).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000305}.
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DR EMBL; AE008691; AAM25902.1; -; Genomic_DNA.
DR RefSeq; WP_011026760.1; NC_003869.1.
DR AlphaFoldDB; Q8R6K6; -.
DR SMR; Q8R6K6; -.
DR STRING; 273068.TTE2799; -.
DR EnsemblBacteria; AAM25902; AAM25902; TTE2799.
DR KEGG; tte:TTE2799; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_4_2_9; -.
DR OMA; WIMPIMI; -.
DR OrthoDB; 524437at2; -.
DR Proteomes; UP000000555; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..206
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124781"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 206 AA; 23855 MW; DA947304FCEADC97 CRC64;
MATIAMYLGQ LLEFIHHYVG NYGVAIIVFT VFIRILLLPF YIQQMAMMKK MKEIQPLVEE
LKKKYGKDPQ KLNMETMKLY QEKKINPFGG CLPMLLPLII LWPLFTMLRT YPAFSTASFL
WMHSLAERDP YYIIPILATV TTYISSAMVA TDKSQNSMNI MMSLFMGWIT VTLPAGVGIY
WVTSNIFQIV QQYIFMRETK TLKGES
