ID   YIDC_CAMJE              Reviewed;         528 AA.
AC   Q9PNX7; Q0P9U1;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=Cj0958c;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; AL111168; CAL35078.1; -; Genomic_DNA.
DR   PIR; E81370; E81370.
DR   RefSeq; WP_002853384.1; NC_002163.1.
DR   RefSeq; YP_002344356.1; NC_002163.1.
DR   AlphaFoldDB; Q9PNX7; -.
DR   SMR; Q9PNX7; -.
DR   STRING; 192222.Cj0958c; -.
DR   PaxDb; Q9PNX7; -.
DR   PRIDE; Q9PNX7; -.
DR   EnsemblBacteria; CAL35078; CAL35078; Cj0958c.
DR   GeneID; 904358; -.
DR   KEGG; cje:Cj0958c; -.
DR   PATRIC; fig|192222.6.peg.942; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_3_1_7; -.
DR   OMA; YKGMVSM; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..528
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124700"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   528 AA;  60828 MW;  069C3B185722FC6D CRC64;
     MNNSNNIFQQ KRILLAVVIS FLFFVIYDYF FIPKQPLKIE QNITQKNQQN TSINNTPNIQ
     NATTNTPSAA LVSQDSVISK VQSKHFEAQI DSFGRISAFY LKDRKYQNEK GEFINLVSKE
     NSPYPLEMRF SDPSINSEAF KIPYVANASN LFVDENGSQV LKLTQNLSGL KIEKDITFYP
     KGNYEIEVKL SKNANYFISP GYRPNIAVDS YTVHGALVMD NKETIETYKD GDVEKDESAN
     NVVMTSAFDR YYATFFYNFD KPLNVAISKD ANQNPIVFAY SDNEFKAGGY IGSKEHVILR
     SIDPRLEAVV EYGWFTFIAK PMFEFLNFLH QYIGNWGWAI VVMTLIVRII LFPLTYKSMI
     SMNKLKDLAP KMKDIRERYK GDPQKMNMHM MELYKKHGAN PMSGCLPILL QIPIFFAIYR
     VLLNAIELKA APWAFWIHDL SVMDPYFILP ILMGATMFLQ QLITPMTIQD PMQAKIMKFL
     PVIFTFFFIT FPAGLTLYWF VNNLCSLVQQ WVINKIFAKE HHKKTSGA