ID   YIDC_CAUVN              Reviewed;         615 AA.
AC   B8H1E8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=CCNA_00806;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP001340; ACL94271.1; -; Genomic_DNA.
DR   RefSeq; WP_010918653.1; NC_011916.1.
DR   RefSeq; YP_002516179.1; NC_011916.1.
DR   AlphaFoldDB; B8H1E8; -.
DR   SMR; B8H1E8; -.
DR   PRIDE; B8H1E8; -.
DR   EnsemblBacteria; ACL94271; ACL94271; CCNA_00806.
DR   GeneID; 7329842; -.
DR   KEGG; ccs:CCNA_00806; -.
DR   PATRIC; fig|565050.3.peg.795; -.
DR   HOGENOM; CLU_016535_1_0_5; -.
DR   OMA; INPVAGC; -.
DR   OrthoDB; 524437at2; -.
DR   PhylomeDB; B8H1E8; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..615
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000187645"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        556..576
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   615 AA;  68428 MW;  D4850F612A10CEDC CRC64;
     MQNDNKNTLM FIVSAFAILI GYQFFVLGPQ QKKAEAEFRA KKAAEQQSAA KAGVTLDANG
     NPAPLRLSRD AAKALSPRIE VDTPALSGSI ALKGARIDDL FLRKYDETTK KDSPPVELFR
     PEGAEHAWFA DFGWAGANLP GLPDSRTVWT AAPGQVLRPN SPVTLTYDNG LGLTFTRVIA
     VDDQAMFTVT DSVKNNGTNG LQLAPYATVQ RQGISDALGK NQIVHEGAIG VLGATDEQKL
     EMAKYGKWKK DKPLQSFDSV GGWTGITDKY WLAALIPGQN QAIKAQYRVT NVAGIDVYDV
     NFLGPVQVLN PGATVSQTTR LFAGAKTVPL LRKYEYGATP APAIWEFWNK TKAEIPRFDD
     AVDWGMFRFF TRPIFNILEV FYKLVGNFGL AILLLTVVLK LVLYPMADKS YESMAKMKKI
     APEVEKLKAK HKDDPAKQQQ EMMALYQKEK INPMMGCLPM LIQIPVFYAL YKVLTVTIEM
     RHAPFFGWIQ DLSAPDPTTM FNLFGLIPWD PGSLPLIGAM IAHLGVWPLL YGFTMWLTTA
     MNPPAGDPIQ QKIFQWFPVI FTFTLSGFAV GLVIYWCWSN VLTIFQQYII MRRYKVENPI
     DQIIARLRGK TAGAT