YIDC_CERS4
ID YIDC_CERS4 Reviewed; 623 AA.
AC Q3IYY6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=RHOS4_26800;
GN ORFNames=RSP_1064;
OS Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS sphaeroides).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Cereibacter.
OX NCBI_TaxID=272943;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC / NCIMB 8253 / ATH 2.4.1.;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; CP000143; ABA80248.1; -; Genomic_DNA.
DR RefSeq; WP_011338690.1; NZ_CP030271.1.
DR RefSeq; YP_354149.1; NC_007493.2.
DR AlphaFoldDB; Q3IYY6; -.
DR SMR; Q3IYY6; -.
DR STRING; 272943.RSP_1064; -.
DR EnsemblBacteria; ABA80248; ABA80248; RSP_1064.
DR KEGG; rsp:RSP_1064; -.
DR PATRIC; fig|272943.9.peg.3038; -.
DR eggNOG; COG0706; Bacteria.
DR OMA; INPVAGC; -.
DR PhylomeDB; Q3IYY6; -.
DR Proteomes; UP000002703; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..623
FT /note="Membrane protein insertase YidC"
FT /id="PRO_1000070153"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 601..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 68647 MW; 61D429AC9657CC1E CRC64;
MDDQNKNLIL ATGLSFLVIM VWFFLFPPPE AVTEGEPTVA TQQTAVAPSA TPDAPTTAVP
PDADLPETQR VVIDTPRLQG SISMLGGRLD DLSLKSYHET LDPQSQIVRL LSPVGQPNAY
YALYGWTPAG ALGYEDVPGA NTTWTQVGSG ALGVDQPVTL QWDNGKGLVF TRTISVDDHY
MFSVAQTVEN NSGQAVQLAP YGIVARHGKP LNLQNFFVLH EGVVGRADGK LTETKYDKVA
ELPQVAREGA QAEVIDAQQD GWIGFTDKYW MTTLIPQQGQ PFTSVTKYVP GADIYQAETR
EQLVTVAPGA TAEVSSRLFA GAKEWETIRA YQNEGATEPT EGAEPIPGFI DSIDWGWFFF
LTKPIFTVLH WLNHMIGNMG LAIIALTFLL KALVLPLAYK SYVSMARMKE LQPELEALRE
RAGDDKMLMQ REMMRLYKEK QVNPAAGCLP ILIQIPIFFS LYKVIFVTIE LRHAPFFGWL
KDLSAPDPSS IFNFFGLAPW AAPTPGTTMA LIFIGALPIL LGVSMWLQQK LNPAPGDKAQ
AMIFAWMPWV FMFMLGHFAS GLVLYWIVNN LITFTQQYVI MRSHGHHPDI FGNIKASFSR
KPAAQPAGKA ANDGAAPAKK RKP
