ID   YIDC_CHLCV              Reviewed;         794 AA.
AC   P59809;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
DE   Flags: Precursor;
GN   Name=yidC; OrderedLocusNames=CCA_00472;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE015925; AAP05217.1; -; Genomic_DNA.
DR   RefSeq; WP_011006433.1; NC_003361.3.
DR   AlphaFoldDB; P59809; -.
DR   SMR; P59809; -.
DR   STRING; 227941.CCA_00472; -.
DR   EnsemblBacteria; AAP05217; AAP05217; CCA_00472.
DR   KEGG; cca:CCA_00472; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_019734_0_0_0; -.
DR   OMA; LNIYWLS; -.
DR   OrthoDB; 52448at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Lipoprotein; Membrane;
KW   Palmitate; Protein transport; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..794
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124703"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        548..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        570..590
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        641..661
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        693..713
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        740..760
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   794 AA;  88952 MW;  9EDCF05E73709133 CRC64;
     MNKRSLLFVS LIGIAFVGCQ IFFGYNDFRS CRTLTEKQKT ITEQVLAATK SMGLSVSPWT
     TSLEEETNKN HYAVRVGDKL LLLNQGGSAS SVYSSGVRWN FIEETTACDN IHVALYGEAN
     ETTTPSNMGK VFLPVTNEDL PVLVVEFRNN QEPVVFLGQY KQEQGKVYNK DSAVYGTSLV
     FWRSGNEYLP LGIYNSKEER LESLDLPITK AAVFSDSKSA NAGANSAQYF VLSNEYMQLI
     VSQESGSIEG INLPFSSEDN KSIVNEIGFD RELKAQVPSE ASFPGLPSVG ANNQPVSDTV
     GGYYPLLRRG ILSDAKKRTP SSYHALNIVS GRELTNSVAS GYRVSTFNST MLELESNDGS
     IKKTYKLPQQ QPYAFEVEVG VNRASDDLWI TSGIPEVEIM SNAFTPAIKY HVIKKNKGQL
     DKVKLPKAKD PLALRSGVYP QWILNSNGYF GIILSPLTDI PAGYAASYVP GSSVPTRLSL
     LSPKNQAYPA SKYPGYETLL PLPQKEGTHR FLVYAGPLAD PTLRVLDKAY TNSKGESPQY
     LDCITFRGFF AFITEPFAAL LFIIMKFFRM ITGSWGISII LLTVFLKLLL YPLNAWSIRS
     MRRMQKLSPY IQEIQQKYKK EPKRAQMEVM ALYKTNKVNP ITGCLPLLIQ LPFLIVMFDL
     LKSSFLLRGA SFIPGWIDNL TAPDVLFSWT TPVWFLGNEF HLLPILLGIV MFAQQKISAS
     KKKGPATDQQ RQQETMGTMM ALLFTFMFYN FPSGLNIYWF SSMLLGLIQQ WFTNKILDSK
     HLKNEISVNK KKQR