ID   YIDC_CHLPN              Reviewed;         795 AA.
AC   Q7VQ46; Q9JS24; Q9Z8M8;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   21-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
DE   Flags: Precursor;
GN   Name=yidC; OrderedLocusNames=CPn_0310, CP_0448, CpB0319;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP98252.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE001363; AAD18459.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38286.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98520.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98252.1; ALT_INIT; Genomic_DNA.
DR   PIR; E81575; E81575.
DR   PIR; F86529; F86529.
DR   PIR; G72092; G72092.
DR   RefSeq; NP_224515.1; NC_000922.1.
DR   RefSeq; WP_010892072.1; NZ_LN846995.1.
DR   AlphaFoldDB; Q7VQ46; -.
DR   STRING; 115711.CP_0448; -.
DR   EnsemblBacteria; AAD18459; AAD18459; CPn_0310.
DR   EnsemblBacteria; AAF38286; AAF38286; CP_0448.
DR   GeneID; 45050359; -.
DR   KEGG; cpa:CP_0448; -.
DR   KEGG; cpj:60IM; -.
DR   KEGG; cpn:CPn_0310; -.
DR   KEGG; cpt:CpB0319; -.
DR   PATRIC; fig|115713.3.peg.344; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_019734_0_0_0; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Lipoprotein; Membrane;
KW   Palmitate; Protein transport; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..795
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124705"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        549..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        571..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        642..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        694..714
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        741..761
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        435
FT                   /note="V -> I (in Ref. 1; AAD18459)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   795 AA;  89319 MW;  57CF703057B9A179 CRC64;
     MNKRTLLFVS LIGIAFVGCQ IFFGYNEFRS CKNLAEKQRK ISEQTLAAVE SVGLSVASWD
     TDVNGEEHKN NYAVRVGDKL FLLHNGEAAQ SVYSSGESWS FVDHKCGFDN IHLALYRQQG
     SSFNPTNTGK VFLPTNHEGL PVLVVEFRNN KEPLVFLGEY AQGRISNKDS TIFGTALVFW
     RSGSDYIPLG LYDSREEKLV SLDLPITRAV IFGNDQDSAK SSDTANHYVL FNDYMQIIVS
     EESGSIEGIN LPFASTNNKS IVNEIGFDRD LASEKSPEAL FPGLSSKLPD GQQAKNSIGG
     YYPLLRRGLL SDSKKLLPLE YHALNVVSGR ELATPVALRY RVLSYTPHSI QLESLDRSVQ
     KVYKLPENPE EKPYVFETAI TLTKETEDVW VTSGVPEVEI MSNASAPTIK YRVIKKNKGS
     LDKVKLPKVK EPLAVRRGVY PQWILNSNGY FGIILTPLSE IASGYGSLYI SGSTAPTRLS
     AISPKNQLYP VSKYPGYETL LPLPKDAGTH RFLVYAGPLA EPTLKVLDKT ITQEKGENPE
     YLDSISFRGV FAFITAPFAA LLFIIMKFFK LVTGSWGISI ILLTVFLKLL LYPLNAWSIR
     SMRRMQILSP YIQQIQQKYK NEPKRAQMEI MGLYKTNKVN PITGCLPLLI QLPFLIAMFD
     LLKSSFLLRG ASFIPGWIDN LTAPDVLFSW QTSIWFIGNE FHLLPILLGI VMFLQQKVTS
     LHKKGPVTDQ QKQQQVMGNM MAILFTAMFY NFPSGLNIYW LSSMILGVVQ QWITNKILDS
     KHLKNEVVLN NKKHR