ID   YIDC_CHLTR              Reviewed;         787 AA.
AC   O84253;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
DE   Flags: Precursor;
GN   Name=yidC; OrderedLocusNames=CT_251;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE001273; AAC67844.1; -; Genomic_DNA.
DR   PIR; E71537; E71537.
DR   RefSeq; NP_219756.1; NC_000117.1.
DR   RefSeq; WP_010725139.1; NC_000117.1.
DR   AlphaFoldDB; O84253; -.
DR   STRING; 813.O172_01360; -.
DR   EnsemblBacteria; AAC67844; AAC67844; CT_251.
DR   GeneID; 884867; -.
DR   KEGG; ctr:CT_251; -.
DR   PATRIC; fig|272561.5.peg.268; -.
DR   HOGENOM; CLU_019734_0_0_0; -.
DR   InParanoid; O84253; -.
DR   OMA; LNIYWLS; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR   GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Lipoprotein; Membrane;
KW   Palmitate; Protein transport; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..787
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124707"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        565..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        636..656
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        688..708
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        735..755
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   787 AA;  88024 MW;  64592E3BC8EEB54B CRC64;
     MRMNKRTLLF VSLVSAAFLG CQIFFGYRDL KSCQDLAEKQ RAISEQILAS TEQLSVVPWT
     ASLEESESVN QYAIRLGNRL LLLTKGGSHP EVYSRGTYWS LIEQTSTFGG ILVSLYGETG
     QEVLSKGSSV YLPNQRDAFP VLVAEFRSNQ EPLVFLGEYK DGKIANKAGA IYGTSLVFLN
     TGNGFVPLGI YNSKEECVES LDLPMARAVV FADKENPTAS GSYYMLSNEY MQIVVSQESG
     AIEGINLPFA SDQEENKSIV NEIGFDRELA INSPSEASFP GVETIDSQRQ NIANVVGGYY
     PLLRRGTLSD VKKRVPAQYQ ALNIVSGREL ASPVATGFRV VSFDNKTLIL ESGDGGIRRT
     YSLGEQPYAF ELEIQTTQGR EDLWITSGVP EVEIMSNAFV PAVKYHAVKK NKSDLFNVKL
     PKAKDSLLVR NNATPQWILN SNGYFGVILT PRIPIPAGYA SSFIPGNVVP TRLSQLPPKD
     QAYPASKYPG YTAMLPLPKE AGRYQFMVYA GPLADPTLKA LDRANANSKG ETPEYVDAIA
     FRGFFSFITE PFAALLFVIM KFFKFLTGSW GISIILLTIV LKLLLYPLNA WSIRSMRRMQ
     KLSPYIQEIQ QKYKREPKRA QMEIMALYKM NKVNPITGCL PLLIQIPFLI AMFDLLKSSF
     LLRGASFIPG WIDNLTAPDV LFSWETPIWF IGKEFHLLPI LLGVVMFAQQ KISAVKRSGP
     ASDQQRQQEA MGTMMALLFT FMFYNFPSGL NIYWFSSMLL GVIQQWVTNK ILDEKHLQHE
     VIINKKR