ID   YIDC_COREF              Reviewed;         397 AA.
AC   Q8FLS3;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=CE2787;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000035; BAC19597.1; -; Genomic_DNA.
DR   RefSeq; WP_006768844.1; NZ_GG700685.1.
DR   AlphaFoldDB; Q8FLS3; -.
DR   SMR; Q8FLS3; -.
DR   STRING; 196164.23494631; -.
DR   EnsemblBacteria; BAC19597; BAC19597; BAC19597.
DR   KEGG; cef:CE2787; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_2_0_11; -.
DR   OMA; DGCIPAL; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..397
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124708"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          327..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        327..387
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   397 AA;  45512 MW;  0A52CD19EBF9CD12 CRC64;
     MLDFLIYPVS GVMKLWHLLL HNGLGLDDSL AWFISLFGLV ITVRAIIAPF TWKMYKSGRL
     TAQIRPKRVA IAEEFKGRHD EDSIREMQQK YKDLNKEYGI NPFAGCVPTL IQIPVILGLY
     QVLLLMARPE GGLENPVPRS IGFLSAEEVQ SFLQGRVFNV PLPAYVTMPA EQLTFLGTTR
     EDVLSFVLPL FIVAAVFTAF NMALSTYRNI QTNDYASNIS NGMFKAFLWL AVLAPLFPLV
     LGLTGPFPTA IALYWVANNL WTFGQTAIMH YIIERNYPLT EEFKEHHAAQ RATYREQQRK
     KRAFLWTRRK NRLMMILTPH RAAELHAQNA EMTRERTERI RAEKATKKEI ATKRRAAERK
     INQQKMEEAR RRRQARRAGD KSNGEQPETD ATDPSGK