YIDC_COXBU
ID YIDC_COXBU Reviewed; 566 AA.
AC P45650;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 09-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=CBU_1920;
OS Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=227377;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Nine Mile phase I / Bratislava;
RX PubMed=8071197; DOI=10.1128/jb.176.17.5233-5243.1994;
RA Suhan M., Chen S.Y., Thompson H.A., Hoover T.A., Hill A., Williams J.C.;
RT "Cloning and characterization of an autonomous replication sequence from
RT Coxiella burnetii.";
RL J. Bacteriol. 176:5233-5243(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSA 493 / Nine Mile phase I;
RX PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA Fraser C.M., Heidelberg J.F.;
RT "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA56919.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAA56921.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAA56921.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U10529; AAA56919.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U10529; AAA56921.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE016828; AAO91411.1; -; Genomic_DNA.
DR PIR; I40654; I40654.
DR PIR; I40656; I40656.
DR RefSeq; NP_820897.1; NC_002971.3.
DR RefSeq; WP_010958538.1; NC_002971.4.
DR AlphaFoldDB; P45650; -.
DR SMR; P45650; -.
DR STRING; 227377.CBU_1920; -.
DR EnsemblBacteria; AAO91411; AAO91411; CBU_1920.
DR GeneID; 1209833; -.
DR KEGG; cbu:CBU_1920; -.
DR PATRIC; fig|227377.7.peg.1904; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_3_0_6; -.
DR OMA; INPVAGC; -.
DR Proteomes; UP000002671; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..566
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124710"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ SEQUENCE 566 AA; 64526 MW; B8D96F89ECF59FFA CRC64;
MDIKRIILYV IVALLAIALF NAWQRDYPPT PKPTPTVEQP TANGDHPTAY TPPAFTPGAA
EKTKKAGTIA FTSKVPEARL ITVRTDVLDV EIDTQGGNIV SAKLPKYPVS LEEKQTPVQI
LSGEPNELYI AQSGLTNGNG QPTTVQFESE KKQYVLENGQ NQLIVQLTGR APDGLLVTKT
YTFHRDDYAI HLAYQVKNNT SKPWQGSLYT QITRRQPPTE HHHFYVRSYN GASMGSPQTP
YEKLSYESLD KQNIDRTSQS GWIAMQQHYF LSAWVPGNPE LTYHYYSHVI PASDEPNVYV
VGFVSPQMNV AAGSEAATHA TLYVGPEIAK RLKGLAPGLE RTIDYGWLWP ISMLLFWILS
AVHAVVKNWG WSIIITTILI KIVFYWFSAK SFRSMARMRE MQPRIQALKE RHGDDRQALS
RATMELYRKE KINPLGGCLP MLIQVPVFIA FYYVIIESVQ LRQAPFIFWI HDLSVKDPYY
ILPIIMGLSM LAQQWVSPTS PDPTQQKMMW ILPVIFTVFF INFPAGLVLY WITNNVVQTL
QQWYVNKTYE SHKAKLKARR ARKRKR
