ID   YIDC_DEIRA              Reviewed;         428 AA.
AC   Q9RSH5;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=DR_2149;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000513; AAF11697.1; -; Genomic_DNA.
DR   PIR; H75307; H75307.
DR   RefSeq; NP_295872.1; NC_001263.1.
DR   RefSeq; WP_010888780.1; NZ_CP015081.1.
DR   AlphaFoldDB; Q9RSH5; -.
DR   SMR; Q9RSH5; -.
DR   STRING; 243230.DR_2149; -.
DR   EnsemblBacteria; AAF11697; AAF11697; DR_2149.
DR   KEGG; dra:DR_2149; -.
DR   PATRIC; fig|243230.17.peg.2374; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_552889_0_0_0; -.
DR   InParanoid; Q9RSH5; -.
DR   OMA; WPLMHQQ; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR   GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..428
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124711"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  47173 MW;  C5DC159AA6FE9753 CRC64;
     MVAGRKAFAL QAGDALSPDK PAEAQPAQVK TDLAANRQDA VFRYAQNGVQ VTKTITLHPR
     NFKVDVRTEV RNGPAQVNML FPGLGKADNP RVQAVPVGGQ PASVQGSGTL SVQNIQYAAL
     QENPSQIAHA LIVRPQQGTK VDVQLTGGPQ GLVTATLPAT SSLEVYGGKN ELIHLYQSGY
     TELPGLFQPN FFGQISLLIV KLMEALYKVI GNWGLVIMAL TILLRLVMWP LMQAQGRTTA
     RMQLVQPLQK EIQEKYKGKT DPESQRAMQM EMAQLMRDYQ VNPAGCFSTL LPFPVLIALW
     ATIRNFEFDS GFLWLPDLAT PDPFYILAVI YLFVNLGQLY VSTRKTPEMF RQQAMIYLVF
     LYFALTFPSG VTLYIILSTI IGIVQQIIIN KQVEHETASL GQTVQKVAPG TRPASKTTVT
     KTIDAPKK