YIDC_ECOUT
ID YIDC_ECOUT Reviewed; 548 AA.
AC Q1R4M9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=UTI89_C4258;
OS Escherichia coli (strain UTI89 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=364106;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTI89 / UPEC;
RX PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA Gordon J.I.;
RT "Identification of genes subject to positive selection in uropathogenic
RT strains of Escherichia coli: a comparative genomics approach.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; CP000243; ABE09685.1; -; Genomic_DNA.
DR RefSeq; WP_000378258.1; NC_007946.1.
DR PDB; 3WVF; X-ray; 3.20 A; A/B=1-540.
DR PDBsum; 3WVF; -.
DR AlphaFoldDB; Q1R4M9; -.
DR SMR; Q1R4M9; -.
DR EnsemblBacteria; ABE09685; ABE09685; UTI89_C4258.
DR GeneID; 67417696; -.
DR KEGG; eci:UTI89_C4258; -.
DR HOGENOM; CLU_016535_3_0_6; -.
DR OMA; INPVAGC; -.
DR Proteomes; UP000001952; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Chaperone; Membrane;
KW Protein transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..548
FT /note="Membrane protein insertase YidC"
FT /id="PRO_1000070089"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 28..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 60..64
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 69..73
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 78..90
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 95..100
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 107..118
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 123..125
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 136..139
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 145..154
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 160..168
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 173..181
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 184..186
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 188..201
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 220..224
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 226..229
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 231..233
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 235..239
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 245..250
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 252..256
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 258..270
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 272..278
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 283..289
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 293..295
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 300..311
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 314..320
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 324..327
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 334..351
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 354..368
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 370..397
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 401..415
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 424..442
FT /evidence="ECO:0007829|PDB:3WVF"
FT TURN 445..448
FT /evidence="ECO:0007829|PDB:3WVF"
FT STRAND 458..460
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 466..476
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 494..496
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 498..505
FT /evidence="ECO:0007829|PDB:3WVF"
FT TURN 506..508
FT /evidence="ECO:0007829|PDB:3WVF"
FT HELIX 511..527
FT /evidence="ECO:0007829|PDB:3WVF"
SQ SEQUENCE 548 AA; 61540 MW; 8A634F07699F0D94 CRC64;
MDSQRNLLVI ALLFVSFMIW QAWEQDKNPQ PQAQQTTQTT TTAAGSAADQ GVPASGQGKL
ISVKTDVLDL TINTRGGDVE QALLPAYPKE LNSTQPFQLL ETSPQFIYQA QSGLTGRDGP
DNPANGPRPL YNVEKDAYVL AEGQNELQVP MTYTDAAGNT FTKTFVLKRG DYAVNVNYNV
QNAGEKPLEI STFGQLKQSI TLPPHLDTGS SNFALHTFRG AAYSTPDEKY EKYKFDTIAD
NENLNISSKG GWVAMLQQYF ATAWIPHNDG TNNFYTANLG NGIAAIGYKS QPVLVQPGQT
GAMNSTLWVG PEIQDKMAAV APHLDLTVDY GWLWFISQPL FKLLKWIHSF VGNWGFSIII
ITFIVRGIMY PLTKAQYTSM AKMRMLQPKI QAMRERLGDD KQRISQEMMA LYKAEKVNPL
GGCFPLLIQM PIFLALYYML MGSVELRQAP FALWIHDLSA QDPYYILPIL MGVTMFFIQK
MSPTTVTDPM QQKIMTFMPV IFTVFFLWFP SGLVLYYIVS NLVTIIQQQL IYRGLEKRGL
HSREKKKS
