ID   YIDC_ENDTX              Reviewed;         519 AA.
AC   B1GZ50;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=TGRD_049;
OS   Endomicrobium trichonymphae.
OC   Bacteria; Elusimicrobia; Endomicrobia; Endomicrobiales; Endomicrobiaceae;
OC   Endomicrobium.
OX   NCBI_TaxID=1408204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18391199; DOI=10.1073/pnas.0801389105;
RA   Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T.,
RA   Sakaki Y., Toyoda A., Hattori M., Ohkuma M.;
RT   "Complete genome of the uncultured termite group 1 bacteria in a single
RT   host protist cell.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; AP009510; BAG13532.1; -; Genomic_DNA.
DR   RefSeq; WP_015423061.1; NC_020419.1.
DR   RefSeq; YP_001955993.1; NC_020419.1.
DR   AlphaFoldDB; B1GZ50; -.
DR   SMR; B1GZ50; -.
DR   STRING; 471821.TGRD_049; -.
DR   EnsemblBacteria; BAG13532; BAG13532; TGRD_049.
DR   KEGG; rsd:TGRD_049; -.
DR   PATRIC; fig|471821.5.peg.85; -.
DR   HOGENOM; CLU_016535_3_0_0; -.
DR   OMA; EHINIET; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000001691; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..519
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000187712"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        471..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   519 AA;  60133 MW;  747CAAAD757A2FAA CRC64;
     MQKNSILFVT LSAFTVFIWY FFFAQPSEQS YRQMMQLQNT VAVSESGVNK FKNADLNEFQ
     IDDIYAKEEH INIETEQYKA VLTNKGGGVL SWSVKEKNGQ WVDLVFPESA PVMANFPNLT
     YKVVSKSAEK IVFEYASKEG WKITKIYNLS DLYMHNLNIS VEKNAKTPFP QIDLKWGPGL
     GTDSKELKEN ISLTRALVYT AVKPNKLKKL KDNFEPASLC KWTAVDNRYF LVAFIPKNSM
     DFDKILFSRL EKKHPCSVIL KAAEPKDVDK KDYSVNFYLG PKDYKYLKTY DLGLEKTVDF
     GFFGFLGKIA FSILVFFYKL THNYGWAIIM LTTIIQILVL PLTLKSFKSS AAMKRVQPVI
     KDIQTKYKDN PQRLKAEMLN IYQSQKVNPL GGCLPMLLQL PIFWAFFTML RNAYELRNEG
     WILWVKDLSA ADQFMQFGSF NLNLLPLMMG IGMFFQQRMT TVTSDPTQRK IMYIMPVIFT
     FMFWSFPSGL VLYWLTNSLI SMIEQYFIMK KDAITVKHI