ID   YIDC_ENT38              Reviewed;         548 AA.
AC   A4WGH2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=Ent638_4149;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP000653; ABP62802.1; -; Genomic_DNA.
DR   RefSeq; WP_015961104.1; NC_009436.1.
DR   AlphaFoldDB; A4WGH2; -.
DR   SMR; A4WGH2; -.
DR   STRING; 399742.Ent638_4149; -.
DR   PRIDE; A4WGH2; -.
DR   EnsemblBacteria; ABP62802; ABP62802; Ent638_4149.
DR   GeneID; 66408856; -.
DR   KEGG; ent:Ent638_4149; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_3_0_6; -.
DR   OMA; INPVAGC; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..548
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000070090"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        499..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   REGION          28..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  61482 MW;  BEC4A7ECF6DC87E8 CRC64;
     MDSQRNLLVI ALLFVSFMIW QAWEQDKNPQ PQQQQTTQTT TTAAGSAADQ GVPASGQGKQ
     ITVKTDVLEL TINTRGGDIE QALLLTYPKE LKSNEPFQLL ETTPEFLYQA QSGLTGRDGP
     DNPANGARPL YNVDKDTFVM ADGQNELAIP MTYTDAAGNT FTKTFTLKRG EYAVSVGYNV
     QNTSAKPLEV STFGQLKQSI NLPSHRDTGS SNFALHTFRG AAYSTPDTKY EKYKFDTIAD
     NENLNVSAKG GWVAMLQQYF ATAWVPNNDG VNNFYTANLG NGIAAIGYKS QPVLVQPGQT
     GTLGSTLWVG PEIQNKMAAV APHLDLTVDY GWLWFISQPL FKLLKWIHSF LGNWGFSIIV
     ITFIVRGIMY PLTKAQYTSM AKMRMLQPKI AAMRERLGDD KQRQSQEMMA LYKAEKVNPL
     GGCFPLLIQM PIFLALYYML MGSVELRHAP FALWIHDLSA QDPYYILPIL MGITMFFIQK
     MSPTTVTDPM QQKIMTFMPV IFTVFFLWFP SGLVLYYIVS NLVTILQQQL IYRGLEKRGL
     HSREKKKS