ID   YIDC_HALHL              Reviewed;         550 AA.
AC   A1WWE3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=Hhal_1230;
OS   Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira
OS   halophila (strain DSM 244 / SL1)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Halorhodospira.
OX   NCBI_TaxID=349124;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 244 / SL1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W.,
RA   Richardson P.;
RT   "Complete sequence of Halorhodospira halophila SL1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP000544; ABM62005.1; -; Genomic_DNA.
DR   RefSeq; WP_011814028.1; NC_008789.1.
DR   AlphaFoldDB; A1WWE3; -.
DR   SMR; A1WWE3; -.
DR   STRING; 349124.Hhal_1230; -.
DR   EnsemblBacteria; ABM62005; ABM62005; Hhal_1230.
DR   KEGG; hha:Hhal_1230; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_3_0_6; -.
DR   OMA; INPVAGC; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000000647; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..550
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000070107"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        473..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   REGION          31..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   550 AA;  62975 MW;  5DA2F62A13663B94 CRC64;
     MENQRLILLI ALAGISLLLY FAWEREQMDP AEPVVEEQES EVDQEAPDAP SRAEEPDAGD
     PMAEGVVDPD DEDAKRVRVK TDLIEAEIST QGGDIRQLDL LKHQKASDDP TPYRLLRDEG
     EPLFVAQAGL GGDGPAPGRD ARYEVDQDEF ELAEGEDTLE VPLIWEEDGV KVRKVYTFRR
     DSYLVDVRHE VENNAEDDWA GFQYVQLRRR PDPAGTTPWY IHSFTGGSLY TQEDRFSRIS
     FSDMEDSDLS QDERDGWAAM LQHYFLGVMI PERGETYRYY TRALPQETYL LGMSSPWLQV
     AAGESGQKTN HLFVGPKEQD RLTAVGSALD VDDLRLTVDY GFLTILANPL FWALDQIENL
     VKNWGVAILI LTLLIKIAFY KLSAISYRSM AKMRKVQPKM QQIRERYSDD RQQMNQALME
     LYKKEKINPL GGCLPILVQI PVFIALYWVL VESVELRHAP FMLWIQDLSS RDPYFILPLL
     MGASMLVQMK LNPPPMDPIQ KRVMQVLPFV FTGFFMLFPA GLVLYWLTNN ILSIAQQWYI
     LRQVEKSDTA