YIDC_LEPIN
ID YIDC_LEPIN Reviewed; 627 AA.
AC P97041; Q8F9L4;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=LA_0178;
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX NCBI_TaxID=189518;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Ictero No.1 / Serogroup Icterohaemorrhagiae;
RX PubMed=9666070; DOI=10.1016/s0378-1119(98)00277-7;
RA Takahashi Y., Akase K., Hirano H., Fukunaga M.;
RT "Physical and genetic maps of the Leptospira interrogans serovar
RT icterohaemorrhagiae strain Ictero No.1 chromosome and sequencing of a 19-kb
RT region of the genome containing the 5S rRNA gene.";
RL Gene 215:37-45(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601;
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; AB001721; BAA19448.1; -; Genomic_DNA.
DR EMBL; AB010203; BAA24371.1; -; Genomic_DNA.
DR EMBL; AE010300; AAN47377.1; -; Genomic_DNA.
DR PIR; T00124; T00124.
DR RefSeq; NP_710359.1; NC_004342.2.
DR RefSeq; WP_000390191.1; NC_004342.2.
DR AlphaFoldDB; P97041; -.
DR SMR; P97041; -.
DR STRING; 189518.LA_0178; -.
DR EnsemblBacteria; AAN47377; AAN47377; LA_0178.
DR KEGG; lil:LA_0178; -.
DR PATRIC; fig|189518.3.peg.177; -.
DR HOGENOM; CLU_016535_3_0_12; -.
DR InParanoid; P97041; -.
DR OMA; LWAICER; -.
DR Proteomes; UP000001408; Chromosome I.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..627
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124721"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 33..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 374
FT /note="L -> F (in Ref. 1; BAA19448/BAA24371)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 627 AA; 71456 MW; 9D4DAD8A68E00723 CRC64;
MEDRQTRLFL ALILSMGIWM GVNYFFFPNT STKKNTETKQ TQSDKTSENT KQQITSGKTK
ESNSADPVVQ KEKITPFDTK KSFIVTDSYI VEFSSLGGKI SKFYMKDFTG PNGELIQVAR
KNPETVVVDG KSYQAVELSR DKGFDFNFSD SLVEISDSPW NYIQFSLTED KINHSISFSA
VSPDRSYQLK KEFRFYPSEN YFKLSISIIN FSKEKLSFAS QKNVRYLRTF GSLGPYPKDR
PLSDRDTANF FRFYYLGGSF QDTLDGSSSV GFWSSVGNFF TGNSGTDESF SIKTDKESGV
DFAGTGSRYF IAVADPLDHK PHGIVLDNRP KNESGAVLVY DNILLNPGEN YNLDFASYIG
IRESEGMAFK NPELDPSQSK NSPFVGLSSD LNKSFNQGIT TPFRNGIIWI LKQIYRFTIP
NYGWSIIIFA ILFKLVFYPL NQKQADSMKK MQELSPQLKT INEKFANDPK MRQQKTMELY
KKNNVNPVGG CLPMVIQIPI FIALYTAFSD TIDLWNSPFL WVKDLSEPDV IWTSPAIPYF
TQTGIGLNLL ALLMVGTQVF QTRMTSVSMD PNQKMLMYVM PVMMLYIFWN MPSGVTLYWT
FQNVLSIGQQ WITNHLKKTE EKKKAKV
