ID   YIDC_MALP2              Reviewed;         379 AA.
AC   Q8EU91;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=MYPE10400;
OS   Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Mycoplasmoidaceae; Malacoplasma.
OX   NCBI_TaxID=272633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2;
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an intracellular
RT   bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000026; BAC44825.1; -; Genomic_DNA.
DR   RefSeq; WP_011077853.1; NC_004432.1.
DR   AlphaFoldDB; Q8EU91; -.
DR   SMR; Q8EU91; -.
DR   STRING; 272633.26454497; -.
DR   EnsemblBacteria; BAC44825; BAC44825; BAC44825.
DR   KEGG; mpe:MYPE10400; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_058030_0_0_14; -.
DR   OMA; LMTITRP; -.
DR   OrthoDB; 818983at2; -.
DR   Proteomes; UP000002522; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..379
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124727"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   379 AA;  43338 MW;  9E3DAA549132CEAC CRC64;
     MKNSYINDNF IVSPLWTQAV DPQKEKKEKV VKILKIILKF TKLFIYAFLF LMGLWGCFQT
     MVDPTVKTST TIGSGMEFGF PFGSTGDFRY DLTSGANNEY YAFTSTQWNI SDYGPFFGLF
     VYPGAMLVLS IMYPLRDVWG GLDALLGIFV LLFIIRLITF LISIRSTMQS ERMSEIQGKL
     AEINAKYKDV KKDMAMRQKK QLETQELYKK YNIKPFAMFE QMFVTMPIFL IVYRVVTILR
     PIKVINLFNI WALSASPLSE ITSNLSNGGW VFIFFLLIIV PSQIISQKIP QILAKRRNAN
     ARALSQKGND SAKKMRISQT VVMVVLVFVV VQSPASVGLY WFLSSLFTIA QSVIIHHYIV
     KRKTKGVSLE EKLRELGIK