ID   YIDC_MYCCT              Reviewed;         388 AA.
AC   P43042; Q2SR03;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=MCAP_0868;
OS   Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343
OS   / NCTC 10154).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=340047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8233831; DOI=10.1093/nar/21.20.4816;
RA   Miyata M., Sano K., Okada R., Fukumura T.;
RT   "Mapping of replication initiation site in Mycoplasma capricolum genome by
RT   two-dimensional gel-electrophoretic analysis.";
RL   Nucleic Acids Res. 21:4816-4823(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=California kid / ATCC 27343 / NCTC 10154;
RA   Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O.,
RA   Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; D14982; BAA03620.1; -; Genomic_DNA.
DR   EMBL; CP000123; ABC01268.1; -; Genomic_DNA.
DR   PIR; S42122; S42122.
DR   AlphaFoldDB; P43042; -.
DR   TCDB; 3.A.5.3.1; the general secretory pathway (sec) family.
DR   EnsemblBacteria; ABC01268; ABC01268; MCAP_0868.
DR   KEGG; mcp:MCAP_0868; -.
DR   HOGENOM; CLU_058030_0_0_14; -.
DR   OMA; LMTITRP; -.
DR   PhylomeDB; P43042; -.
DR   Proteomes; UP000001928; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..388
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124722"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   388 AA;  44537 MW;  B0A3F9B6358DF3A9 CRC64;
     MSYLNASKNK KAPKTKKEIF KVVIKWLKVF GFLFILVSML WGCVQMYQAQ YSVNQIVDMT
     GKSVYTPGVS FEIILSSLGE QGSKVHHFVY DKGSFFEYGY NAITSWKETF KLTQSPFYGF
     FVYPTAWILA GMIKLFSGTL NPLLDKSSQL TYGISSIFAI FLTTLLIKGI TLSFGWKSQI
     NQEKMQDIQL KVADIQAKYK DKKDMQSKQK QQLEIQALYK KENMSQFSAL AGSFAPLPFL
     FAIYAIVRST RALKIASVGP IALIEGPWQQ ITAGNYIYII ILAIYLPLQA VSMLLPTLLQ
     MKKQKSITLT EAQKKSRKKQ LIMQVVMMFV FIIIIVSVAT GVCIYWIFSS ILQIIQTYAF
     YLYNEKKRKA GNQERQRRLR QMERMNLK