ID   YIDC_MYCLE              Reviewed;         380 AA.
AC   Q50205; Q9CCX6;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   21-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=ML2710;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8969512; DOI=10.1099/13500872-142-11-3147;
RA   Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G.,
RA   Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.;
RT   "Gene arrangement and organization in an approximately 76 kb fragment
RT   encompassing the oriC region of the chromosome of Mycobacterium leprae.";
RL   Microbiology 142:3147-3161(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB53138.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L39923; AAB53138.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL583926; CAC32242.1; -; Genomic_DNA.
DR   PIR; D87248; D87248.
DR   RefSeq; NP_302731.1; NC_002677.1.
DR   RefSeq; WP_010909049.1; NC_002677.1.
DR   AlphaFoldDB; Q50205; -.
DR   STRING; 272631.ML2710; -.
DR   EnsemblBacteria; CAC32242; CAC32242; CAC32242.
DR   KEGG; mle:ML2710; -.
DR   PATRIC; fig|272631.5.peg.5213; -.
DR   Leproma; ML2710; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_3_0_11; -.
DR   OMA; NFIYYPV; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..380
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124725"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          287..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        70..71
FT                   /note="MQ -> IE (in Ref. 1; AAB53138)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   380 AA;  42879 MW;  EDE4158FA743271D CRC64;
     MSLLPFDFVS LDIVYYPVSW IMWVWYKLFA AVLGPSNFFA WALSVMFLVF TLRALLYKPF
     VRQIRTTRQM QELQPRIRAL QRKYGKDRQR MALEMQKLQR EHGFNPILGC LPMLAQIPVF
     LGLYHALRSF NRTTGGFGQP HMSVTENRMT GNYVFTPVDV GHFLDANLWG APIGAYMTQR
     SGLDAFIDFS RPAVILVGIP MMVLAGVATY FNSRASIARQ SAEAAENPQT ALMNKIALYV
     FPFGVVVGGP FLPLAIILYW FSNNIWTFGQ QHYVFSMIEK EDEAKKQKAI ERRTANAPAP
     GSKPKYVSTT APVSVNGFSK DTMISDDGAK LGSQEADSID WVTETKTATT PADKPDCVGY
     NNNPTSHTRR SGQRTKRRKR