ID   YIDC_MYCPA              Reviewed;         353 AA.
AC   Q9L7M1;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=MAP_4347c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zhang Q., Kapur V.;
RT   "Genomic organization of the Mycobacterium avium subsp. paratuberculosis
RT   origin of replication region.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF222789; AAF33698.1; -; Genomic_DNA.
DR   EMBL; AE016958; AAS06897.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9L7M1; -.
DR   SMR; Q9L7M1; -.
DR   STRING; 262316.MAP_4347c; -.
DR   EnsemblBacteria; AAS06897; AAS06897; MAP_4347c.
DR   KEGG; mpa:MAP_4347c; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_036138_3_0_11; -.
DR   OMA; NFIYYPV; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..353
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124726"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          285..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   353 AA;  39247 MW;  FCBA68ADB523BA90 CRC64;
     MDLLFDFFSL DFVYYPVSWI MWVWYKLFAA MLGPSNFFAW ALSVMFLVFT LRALLYKPFV
     RQIRTTRQMQ ELQPQIKALQ KKYGKDRQRM ALEMQKLQRE HGFNPILGCL PMLAQIPVFL
     GLYHVLRSFN RTTGGFGQPH LSVVQNRLTG NYVFTPTDVG HFLDANLFGA PIGAFMTQRT
     GLDAFTYFSR PAVIAVGLPV MILAGVATYF NSRASVARQS PEAAANPQTA MMNKLALYVF
     PLGVVVGGPF LPLAIILYWF ANNIWTFGQQ HYVFGMIEKE DEAKKQEAIQ RRAANAPAPG
     AKPKRNLKAG AGNGVDADAA QPDAGATEGQ AGGGSDAPSR TPRPGARPKK RKR