ID   YIDC_MYCPN              Reviewed;         385 AA.
AC   P75112;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=MPN_680; ORFNames=MP162;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U00089; AAB95810.1; -; Genomic_DNA.
DR   PIR; S73488; S73488.
DR   RefSeq; NP_110369.1; NC_000912.1.
DR   RefSeq; WP_010875037.1; NC_000912.1.
DR   AlphaFoldDB; P75112; -.
DR   STRING; 272634.MPN_680; -.
DR   EnsemblBacteria; AAB95810; AAB95810; MPN_680.
DR   GeneID; 66608632; -.
DR   KEGG; mpn:MPN_680; -.
DR   PATRIC; fig|272634.6.peg.747; -.
DR   HOGENOM; CLU_058030_0_0_14; -.
DR   OMA; LMTITRP; -.
DR   BioCyc; MPNE272634:G1GJ3-1089-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..385
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124728"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   385 AA;  44239 MW;  C85BB5A28DC5B82D CRC64;
     MPLNLNKKHK ELKTTFNPFW SAAVVNEKNG LKNLKKAWGI IFKVLKVAIF IFLTIVGLWG
     CTQTLAQPWT GTNQLLGSGL EIGYNFGTTG DYRYDLQSNN VGPYFTFSDY TLAYGPFYGW
     FVWPASQIVL PIMYATRVPL GSGPELGFNM ILSLIVLLFL VRLITIVITL NSTLALEKMN
     EVQGKLAEIN AKYKGALDLQ SKRNRQMEIM SLYKKHNIKS SASFVQVFVT LPIFLIIYRI
     VTTLRPIKAI ILFNFWDLSK VPLTEIFSNF TSTGWTFIIF LIIVLPVQFI SQKLPQIWAS
     KRNENAKAHS QKSIEQLNKT KRMQLIFYFV FAVITAFSAA GVGVYWFLNA LFTLLQSYLT
     HLFIVKRRTR RRLTYSKLEQ MLERE