ID   YIDC_MYCPU              Reviewed;         608 AA.
AC   Q98R58;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 3.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=MYPU_1520;
OS   Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX   NCBI_TaxID=272635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAB CTIP;
RX   PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA   Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA   Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT   "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT   pulmonis.";
RL   Nucleic Acids Res. 29:2145-2153(2001).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL445563; CAC13325.1; -; Genomic_DNA.
DR   PIR; H90530; H90530.
DR   RefSeq; WP_010924956.1; NC_002771.1.
DR   AlphaFoldDB; Q98R58; -.
DR   STRING; 272635.MYPU_1520; -.
DR   EnsemblBacteria; CAC13325; CAC13325; CAC13325.
DR   KEGG; mpu:MYPU_1520; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_031187_0_0_14; -.
DR   OMA; MWRVIQS; -.
DR   OrthoDB; 945517at2; -.
DR   BioCyc; MPUL272635:G1GT6-153-MON; -.
DR   Proteomes; UP000000528; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..608
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124729"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        556..576
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   608 AA;  70135 MW;  E49F2EFDE924E4AD CRC64;
     MKRENRSKKY DYFNSSSNNS NKFSKTNFKK YFKIFKLVVY IFLIGLALTG CIQSFVVQSS
     PNVGAGLELY PSKDKVAPRV NVYKKEENGY VKDRNINELL KDEQSLQALK DFSKNHNGVY
     GKTKSSNSAL AILEDNTYID SDGQENKSII YKDNSGKYLF FNDTLTTYDP INKFTDIYAI
     GRLTERDSDA IKFRENNPKI IEHLKLFKVS EVPISREYQP NIKFARDFLQ ALYDKTLKLP
     VYQNILRADG SKYASFNEFL TSLEKRTTNH LKTQLNKQEL SEEDLNSITL SDSESAALNA
     YLTRVNPLIS ENGFTGLKKS LNNADDFELV YSQGEKIAQS DYGQIPVVTW GEYWNYGPFY
     ALLVAPIASF TNWVASAFES GFGIVFAIIV VVVVTRLFIF GLTFKVTFSQ YKQQELQGKK
     AKIDAKYAAY ENNKMMKQRK QKEIQDLYKK HNISPIDFVA SIAWSSPLFI AVWRVIQSVP
     VIKSNFFLGV NFSTASYQEI LAKNWVYLWV VSLALIVQII SQILPRWLAK KKIKERANVY
     EMQSYKKNNK TQNIMLIVFM VFTITLQAGV QIYWIIGGLW TIGQTLFVHH FQKTSFFKNR
     VRPWLDRH