ID   YIDC_MYCTO              Reviewed;         366 AA.
AC   P9WIT4; L0TH52; O53599; P65626; Q7TVC3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=MT4040;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK48406.1; -; Genomic_DNA.
DR   PIR; A70852; A70852.
DR   RefSeq; WP_003899765.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WIT4; -.
DR   SMR; P9WIT4; -.
DR   EnsemblBacteria; AAK48406; AAK48406; MT4040.
DR   GeneID; 45427921; -.
DR   KEGG; mtc:MT4040; -.
DR   PATRIC; fig|83331.31.peg.4346; -.
DR   HOGENOM; CLU_036138_3_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..366
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000427949"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          285..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  40916 MW;  50ED3C7596CA57B9 CRC64;
     MSLLFDFFSL DFIYYPVSWI MWVWYRLFAF VLGPSNFFAW ALSVMFLVFT LRALLYKPFV
     RQIRTTRQMQ ELQPQIKALQ KKYGKDRQRM ALEMQKLQRE HGFNPILGCL PMLAQIPVFL
     GLYHVLRSFN RTTGGFGQPH LSVIENRLTG NYVFSPVDVG HFLDANLFGA PIGAYMTQRS
     GLDAFVDFSR PALIAVGVPV MILAGIATYF NSRASIARQS AEAAANPQTA MMNKLALYVF
     PLGVVVGGPF LPLAIILYWF SNNIWTFGQQ HYVFGMIEKE EEAKKQEAVR RRAANAPAPG
     AKPKRSPKTA PATNAAAPTE AGDTDDGAES DASTERPADT SNPARRNSGP SARTPRPGVR
     PKKRKR