YIDC_NITEU
ID YIDC_NITEU Reviewed; 614 AA.
AC P59810;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=NE0387;
OS Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC
OS 14298).
OC Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=228410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298;
RX PubMed=12700255; DOI=10.1128/jb.185.9.2759-2773.2003;
RA Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L.,
RA Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A.,
RA Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.;
RT "Complete genome sequence of the ammonia-oxidizing bacterium and obligate
RT chemolithoautotroph Nitrosomonas europaea.";
RL J. Bacteriol. 185:2759-2773(2003).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; AL954747; CAD84298.1; -; Genomic_DNA.
DR RefSeq; WP_011111022.1; NC_004757.1.
DR AlphaFoldDB; P59810; -.
DR SMR; P59810; -.
DR STRING; 228410.NE0387; -.
DR EnsemblBacteria; CAD84298; CAD84298; NE0387.
DR KEGG; neu:NE0387; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_3_0_4; -.
DR OMA; INPVAGC; -.
DR OrthoDB; 524437at2; -.
DR PhylomeDB; P59810; -.
DR Proteomes; UP000001416; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..614
FT /note="Membrane protein insertase YidC"
FT /id="PRO_0000124734"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 34..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 68452 MW; 5A45265E8171FB6D CRC64;
MDNKKIVLLI IFSTSLLFLW DAWIKEQEKF NNPPAITQAD SSAGSTQSRN DDSLPVPGSE
LTSSQASPDT NGIPASGGNG DSVTPRLLPS GEQIRVVTDK VIAEIDTIGG DLRRLELLQQ
PSSEDKDTPY ALLYSEAART YIAQSGLVGE GLPNHKTTFR AESDIRNYEL SSGEDKIVIR
LLAPEAQGVQ VIKTYTFHRD SYVIDVGFEV ENKGDATVRP FAYFQMLRDG NPPPAKTMMI
PTFLGAAVYT EEGKYQKIPF SDLDKNKADY PANANNGWIA MLEHYFLTAW LPQQQTPREF
FAKRQSDNLY SAGVIVPAGV IAPGEIAATT MPFYAGPEEQ DNLEGLAPGL DLTVDYGWLT
VIAKPLFRLL SFYHSWTDNW GVAIILLTMT VKLLFFPLSA AGYRSMAKLR LVTPKLKRIQ
DQYKGDRQRM HQAMMEFYKE EKINPMGGCF PILVQIPVFI ALYWTILAAV ELRYAPLALW
IDDLSSPDPF YMLPLLMGIS MFVQTKLNPT PTDPLQAKIM QIMPVAFSAI FFFFPAGLVL
YSLVNNILSI AQQWKITKMY GTAPSKDTPE PPVSKQVNSS ENPETTANSP ADSPKQPQTP
ANNPRKMYKR TRKK
