ID   YIDC_NOSS1              Reviewed;         380 AA.
AC   Q8YRM9;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Membrane protein insertase YidC;
DE   AltName: Full=Foldase YidC;
DE   AltName: Full=Membrane integrase YidC;
DE   AltName: Full=Membrane protein YidC;
GN   Name=yidC; OrderedLocusNames=alr3415;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Probably also aids protein insertion, folding and/or assembly
CC       of membrane complexes destined for the thylakoid. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000019; BAB75114.1; -; Genomic_DNA.
DR   PIR; AH2232; AH2232.
DR   RefSeq; WP_010997565.1; NZ_RSCN01000015.1.
DR   AlphaFoldDB; Q8YRM9; -.
DR   STRING; 103690.17132548; -.
DR   EnsemblBacteria; BAB75114; BAB75114; BAB75114.
DR   KEGG; ana:alr3415; -.
DR   eggNOG; COG0706; Bacteria.
DR   OMA; KITPVMI; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..380
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124685"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          361..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   380 AA;  42146 MW;  16056FAD26618A1E CRC64;
     MDFGIGFLSN NVMLPIIDFF YSVVPSYGLA IVALTLIIRF ALYPLSAGQI RNMRKMRIVQ
     PLMQKRMAEI KERYKDDPQK QQEEMMNVQK EFGNPLAGCL PLLLQMPVLL ALFATLRGSP
     FAGVNYSVNL QIFPSEQIER IQPQAFATPP QNIYIADGEH TKVTAILPGG NKLAVGEKTK
     IQYQTLEGKP FPVLLAEHPE SKLSPEWKIT KGEDRIKIDA EGNIEALQPG DVTIQGTIPG
     LAADKGFLFI DALGRVGAID PDNTIHWDIV GMIVFFGISL YVSQMLSGQN SSGGNPQQDT
     VNKITPVIFS GMFLFFPLPA GVLMYMVIGN VFQTLQTYIL SREPLPEEIQ KIVETQEKQA
     VAEQKTLPFE PKSSKKKTTG