YIDC_PARD8
ID YIDC_PARD8 Reviewed; 633 AA.
AC A6L9D2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BDI_0520;
OS Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS 5825 / NCTC 11152).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Parabacteroides.
OX NCBI_TaxID=435591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152;
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; CP000140; ABR42296.1; -; Genomic_DNA.
DR RefSeq; WP_005855674.1; NC_009615.1.
DR AlphaFoldDB; A6L9D2; -.
DR SMR; A6L9D2; -.
DR STRING; 435591.BDI_0520; -.
DR EnsemblBacteria; ABR42296; ABR42296; BDI_0520.
DR KEGG; pdi:BDI_0520; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_2_0_10; -.
DR OMA; WGIFGWI; -.
DR OrthoDB; 524437at2; -.
DR BioCyc; PDIS435591:G1G5A-535-MON; -.
DR Proteomes; UP000000566; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..633
FT /note="Membrane protein insertase YidC"
FT /id="PRO_1000070130"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT REGION 612..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 73243 MW; BBE2DAAA45E513BC CRC64;
MDKNTLIGFL LIGVVLFAFS WFNRPTPEQL EAQRRYQDSI AKIEYAQQLE LQKQENKSAL
VEDSLENLPD SVRAQRLQQS FGVFGDAMVG TEDYTTLQND VVELRISNKG GRICYARLKE
YDTYNDEPLV LFDEKESNFN FTLVTATNRV VNTSDLYFTP VKGNDPNSVI MRLNTGEGSH
LDFTYTLKPD DYMVQYQILG TGLNGVLAPS TNALDLLWEQ DIRQQEKGRK FEDRYVTLNY
KFMADDVEHL SESKSDSKQI PNRLKWIGYK DMFFSTVLIS QEGFEATTLD SKAIPEGDVL
KQFKTTASVP FDLQGKEATN LSFYFGPNKF ALLKSFDKGV SAEQQLDLEK LVPLGWGIFR
WVNQYFVIPL FDFLGKFIHN YGILILLMTI IVKIILFPLT YKSYMSSAKM RVLRPQVEEI
NAKYPGQDKA MERQKATMEL YSRAGASPMS GCLPMLLQMP ILIALFMFFP SAIELRHQSF
LWAHDLSTYD AIFSWNKYIP IITPYFGNHI SLFCLLMTIT NIFYTKYNME MTNTGQQQMP
GMKAMMYMMP LMFLVFFNQY ASGLTYYYFI STLITIVQTL IFRYTINEDK LLAKLEANKR
KPMKKSGFMK RLEEAQRAQQ ETLRKQQEAK KKR
