ID   YIDC_PELUB              Reviewed;         558 AA.
AC   Q4FNF1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=SAR11_0466;
OS   Pelagibacter ubique (strain HTCC1062).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Pelagibacterales;
OC   Pelagibacteraceae; Candidatus Pelagibacter.
OX   NCBI_TaxID=335992;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC1062;
RX   PubMed=16109880; DOI=10.1126/science.1114057;
RA   Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D.,
RA   Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M.,
RA   Carrington J.C., Mathur E.J.;
RT   "Genome streamlining in a cosmopolitan oceanic bacterium.";
RL   Science 309:1242-1245(2005).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP000084; AAZ21288.1; -; Genomic_DNA.
DR   RefSeq; WP_011281732.1; NC_007205.1.
DR   AlphaFoldDB; Q4FNF1; -.
DR   SMR; Q4FNF1; -.
DR   STRING; 335992.SAR11_0466; -.
DR   EnsemblBacteria; AAZ21288; AAZ21288; SAR11_0466.
DR   GeneID; 66294965; -.
DR   KEGG; pub:SAR11_0466; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_1_0_5; -.
DR   OMA; INPVAGC; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000002528; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..558
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000187685"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        326..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        355..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   558 AA;  63931 MW;  881C9369EAC19250 CRC64;
     MDTRNVIAAI SLSAAVIILY SLFFQPDPAT IKKNLAEQNK IENNEDTPSL DKNENFSKLS
     RADALKENDR IQFENGSVVG SISLKGAAID DLTFKEYNIE LNRNEKITLL SPRNVEDGYL
     IESGFVSTNK NIDIPDASTV WEVSGNNKLT NNNPVKLTWS NTQGITFEKH ISLDDQFLFT
     VKEKIINSSD KSYNFYSYGQ IIRNELPEIS GFYILHEGFL SVLDDELIEE DYDDIQDKKF
     TQIAQDGFVA ISDKFWVTSV IPPKGKEFKT TFDYKNKFRA NYISTKGIEV KANSSIEEKI
     QIIVAAKRVN VIDGYAENLN INKFDLAIDW GFMYFITKPL FFVLDYFFKL LGNYGLAIIA
     VTICIRLAFF PLANFSFKSM GKMKLLAPEM ARLKELHKDD KMKLQQAMMA LYKKEKVNPM
     SGCLPILVQI PVFFALYKVL FVTIEMRHMP FYGWIHDLSD RDPTSLFNVF GLIPWDPPSF
     LLIGAWPIIM GITMWIQQKL NPTPPDPIQA KIFMFFPVFL TVILAPFPAG LVIYWSFNNI
     FTMIQQYIVQ RKMTIKTT