YIDC_PHOV8
ID YIDC_PHOV8 Reviewed; 621 AA.
AC A6L5L6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=BVU_3354;
OS Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Phocaeicola.
OX NCBI_TaxID=435590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC 11154;
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01810}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR EMBL; CP000139; ABR40980.1; -; Genomic_DNA.
DR RefSeq; WP_005840021.1; NC_009614.1.
DR AlphaFoldDB; A6L5L6; -.
DR SMR; A6L5L6; -.
DR STRING; 435590.BVU_3354; -.
DR PRIDE; A6L5L6; -.
DR EnsemblBacteria; ABR40980; ABR40980; BVU_3354.
DR GeneID; 66749749; -.
DR KEGG; bvu:BVU_3354; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_016535_2_0_10; -.
DR OMA; WGIFGWI; -.
DR OrthoDB; 524437at2; -.
DR BioCyc; BVUL435590:G1G59-3476-MON; -.
DR Proteomes; UP000002861; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR038210; YidC_periplasmic.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..621
FT /note="Membrane protein insertase YidC"
FT /id="PRO_1000070060"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ SEQUENCE 621 AA; 70942 MW; 3374C165B976A352 CRC64;
MDKNTLVGFA LIGAVVIGFS IYNRPSQEEM ARAKHYQDSI QAIAQKEAER LAQAATAQSQ
NATLHLDSTS MFYGANQGTE QLTTLENNVV KLTFTNKGGR VCAAILKDYN GQDGKPLMLF
DEKDSGMNFA FEGKNENILT EDMYFQPTNV TDSTVTMRLA ANNGGYIDFD YKLLPDAYMV
NFTIRANGMQ NFFPPALNTV NINWRQRARQ LEKGFSFEQR YTSLTYKPVE KSSDYLNEMK
EAKEDVTDRL DWIAFKNQFF SSVLIADQDF DKASLTSTPQ QEGSGYMKNY TADMTTFFDP
TGKQPTDMQF YFGPNHFKTL LNSNDLSLSQ KDLELEDLVY LGWPIIRWVN RWFTINLFDW
LSGWGLSMGV VLLLMTIIVK VLVYPATYKS YMSSAKMRVL KPYINEINAK YPKKEDALKK
QQETMALYSK YGVSPMGGCL PMLIQMPVFM ALFFFVPNAI ELRQQSFLWA PDLSTYDDII
NWGTNIPLLG NHLSLFCLLF SITNILNTMY TMKQQDMGQQ QMPGMKLMMY IMPVMFIFIF
NGYSSGLNYY YFISGLIGIL TMVILRKTTD EKKLLAMLEA RKEKKSQKNG GKPGGGLMAK
LEALQKEQER LQQERMNKGK K
