ID   YIDC_POLNS              Reviewed;         557 AA.
AC   B1XSN7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=Pnec_1784;
OS   Polynucleobacter necessarius subsp. necessarius (strain STIR1).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Polynucleobacter.
OX   NCBI_TaxID=452638;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=STIR1;
RX   PubMed=24167248; DOI=10.1073/pnas.1316687110;
RA   Boscaro V., Felletti M., Vannini C., Ackerman M.S., Chain P.S.,
RA   Malfatti S., Vergez L.M., Shin M., Doak T.G., Lynch M., Petroni G.;
RT   "Polynucleobacter necessarius, a model for genome reduction in both free-
RT   living and symbiotic bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:18590-18595(2013).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01810}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; CP001010; ACB44836.1; -; Genomic_DNA.
DR   RefSeq; WP_012358594.1; NC_010531.1.
DR   AlphaFoldDB; B1XSN7; -.
DR   SMR; B1XSN7; -.
DR   STRING; 452638.Pnec_1784; -.
DR   EnsemblBacteria; ACB44836; ACB44836; Pnec_1784.
DR   KEGG; pne:Pnec_1784; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_3_0_4; -.
DR   OMA; LWIGPKI; -.
DR   OrthoDB; 524437at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.90; -; 1.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   InterPro; IPR038210; YidC_periplasmic.
DR   InterPro; IPR038221; YidC_periplasmic_sf.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   Pfam; PF14849; YidC_periplas; 1.
DR   PRINTS; PR00701; 60KDINNERMP.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..557
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_1000187687"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   557 AA;  61782 MW;  12E4C4116204A542 CRC64;
     MDFKKTIFWA AFSMSGLMLY NNWQVHEGKP SLFGGAPASA PAVADKATTN NKVDVPTQIS
     GAPSVAATPI INGGAIESAE KFTLQNDVLV LEISASGANV IDAKLLKSLT AENKPVELFQ
     YTPTHKYFAR SGLVSLNNND LPNHTSTFKL VQSGKDGSGR PFAVFASERN GVRLEKTFIL
     NPGSYVVDVG HRVTQSTSNP NPLVLYTEIV RDASQEQKIG PFGGAFSANT FTGPVAYTDK
     EKFNKLEFSA IDKNKITIPT LVAAGEPAWI AMVQHYFASA WIPGDKVARD IYTGRIDNGL
     YRIGMQTPLG MVGPGSTVVE KAKLFVGPQE ERVLETIAPG FELLKDYGYL TILAKPIFWL
     LDNIHFYVGN WGWSIILLTI LIKLVFFPLS AASYKSMARM KEVQPRLVAM KEQYKGEPQK
     LNQAMMEMYR KEKINPLGGC LPVVIQIPVF ISLYWVLLSS VETRGAPWIL WIHDLSVPDP
     YYILPVIMAV SMFVQTKLNP TPPDPIQAKV MMYMPIVFSV MFFFFPAGLV LYWVVNNLLS
     IAQQWQINQM FGKKPAK